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Study Description

We conducted methylation profiling of breast tumor DNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples for 1,550 cases from a cohort of Black women from the Black Women's Health Study (BWHS), the Women's Circle of Health Study (WCHS), and from the Pathways Study using the Illumina MethylationEPIC array. We will examine differentially methylated loci (DML) between ER+ and ER- tumors, and by age at onset of breast cancer. Combining these data with previously analyzed samples (n=385), we will consider associations between reproductive risk factors and top DML by age at diagnosis and ER status, examining the complex relationships between methylation, tumor and patient characteristics, and reproductive risk factors using structural equation modeling.

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Publicly Available Data
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Study Inclusion/Exclusion Criteria

Inclusion Criteria:

  • African American
  • Female
  • Age 22 and older
  • Confirmed invasive breast cancer or ductal carcinoma in situ
Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigators
    • Christine B. Ambrosone, PhD. Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
    • Julie R. Palmer, ScD. Slone Epidemiology Center, Boston University, Boston, MA, USA.
    • Lawrence H. Kushi, ScD. Kaiser Permanente Northern Califonia, Oakland, CA, USA.
    • Michael J. Higgins, PhD. Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Genotyping Center
    • Center for Inherited Disease Research (CIDR). Johns Hopkins University, Baltimore, MD, USA.
  • Funding Source for CIDR Genotyping
    • HHSN268201700006I, NIH contract "High throughput genotyping for studying the genetic contributions to human disease". National Institutes of Health, Bethesda, MD, USA.