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Study Description

This study provides paired tumor normal genomic sequencing data from ~ 200 children with cancer, including both solid tumors and leukemias, done by the Children's Mercy Research Institute (CMRI) and University of Kansas Cancer Center (KUCC). These data include whole genome sequencing (generally, ~20x), whole exome sequencing (generally, ~300x), bulk RNA sequencing (generally, ~80 million reads), and single-cell RNA and ATAC sequencing (>50,000 reads/cell). Additional phenotypic, pathologic, and genetic data, gathered clinically for these samples, are also provided.

  • Study Design:
    • Tumor vs. Matched-Normal
  • Study Type:
    • Case Set
    • Clinical Cohort
    • Clinical Genetic Testing
    • Exome Sequencing
    • Full Transcriptome Sequencing
    • Individual-Level Genomic Data
    • Mixed
    • Probands
    • Repository
    • RNA Sequencing
    • Sequencing
    • Single Cell Analysis
    • Transcriptome Sequencing
    • Tumor
    • Tumor vs. Matched-Normal
    • Whole Genome Sequencing
  • Total number of consented subjects: 193
  • Subject Sample Telemetry Report (SSTR)
Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Study Inclusion/Exclusion Criteria

Inclusion Criteria:

  • Diagnosis of primary cancer
  • Age < 21 years old

Exclusion Criteria: Not applicable

Study History

2015 - 2022: Patient Enrollment and Sequencing

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Genes
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • Roy Jensen, MD. University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA.
  • Co-Principal Investigator
    • Midhat Farooqi, MD, PhD. Children's Mercy Kansas City, Children’s Mercy Research Institute, University of Kansas Cancer Center, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
  • Data Managers
    • Lisa Lansdon, PhD. Children's Mercy Kansas City, Kansas City, MO, USA.
    • Byunggil Yoo, MS. Children's Mercy Kansas City, Kansas City, MO, USA.
  • Data Submitter
    • Irina Pushel, PhD. Children's Mercy Kansas City, Kansas City, MO, USA.
  • Sequencing Center
    • Genomic Medicine Center. Children's Mercy Kansas City, Kansas City, MO, USA.
  • Funding Sources
    • National Cancer Institute, Center for Biomedical Informatics and Information Technology 3P30CA168524-09S3. National Institutes of Health, Bethesda, MD, USA.
    • Big Slick.
    • Children's Mercy Research Institute.
    • Black & Veatch.
    • Braden's HOPE For Childhood Cancer.
    • Curing Kid's Cancer.
    • Alex’s Lemonade Stand.
    • Noah's Bandage Project.
    • Children's Mercy Cancer Center Auxiliary Research Fund.
    • Department of Defense, U.S. Army Medical Research and Development Command W81XWH-20-1-0358. Fort Detrick, MD, USA.
    • Masonic Cancer Alliance, Partner's Advisory Board.