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Study Description

This goal of this project is to perform systematic analyses of germline genetic alterations in sporadic and familial multiple myeloma (MM) to discover candidate genes from these exome data. In this proposal, we will build on our prior work and pre-existing genomic data to prioritize, identify and validate novel candidate genes conferring susceptibility to MM.

Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Study Inclusion/Exclusion Criteria

The inclusion criteria is anyone with MM, but the preferred criteria are:

  1. Age of Onset <65, Caucasian AND/OR
  2. Family History of MM in FDR, SDR or a family history of lymphoma in FDR/SDR
  3. Availability of 500ng of sequencing quality DNA
  4. Institutional certification for data sharing in dbGAP
  5. Availability of core variables
    1. Core variables are age, gender, age at diagnosis, ethnicity

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • Vijai Joseph, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Funding Source for Vijai Joseph
    • R21CA209533. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Sequencing Center
    • Center for Inherited Disease Research (CIDR). Johns Hopkins University, Baltimore, MD, USA.
  • Funding Source for CIDR Sequencing
    • HHSN268201700006I, NIH contract "High throughput genotyping for studying the genetic contributions to human disease". National Institutes of Health, Bethesda, MD, USA.