Single Cell Omics Resolves Transcriptional Alterations in Sjogren's Syndrome

Single cell omics resolves transcriptional alterations in Sjogren's Syndrome. This data compares the single cell transcriptional profiles of the minor salivary glands between Sjogren's Syndrome patients and non-Sjogren's Syndrome subjects. Portions of this data were reported in two separate publications: Huang & Perez, et al., 2021 Nature Medicine and Yin, et al., 2021, Frontiers in Immunology .

• Study Weblinks:
  • Characterization of Diseases With Salivary Gland Involvement
• Study Design:
  • Cross-Sectional
• Study Type:
  • Cross-Sectional
  • Single Cell Analysis
• Total number of consented subjects: 12
• Subject Sample Telemetry Report (SSTR)

• BioProject
• PubMed
• Sequence Read Archive
• BioSample
• MeSH
• Clinical Trials
  • NCT02327884

Inclusion Criteria:

• older than 4 years, affected or suspected of being affected with a disease/disorder involving the salivary glands, or a relative of a patient who is affected with a salivary gland disease/disorder.
• 18 years or older with active hepatitis with or without sicca symptoms.
• 18 years or older, healthy, agree to have blood, urine, saliva or other tissue samples collected and studied.

Exclusion Criteria:

• not able to give consent/assent or parental/guardian consent
• NIH employees who directly report to the principal investigator
• significant concurrent medical condition or other circumstances that may affect the participant's ability to tolerate or complete the study, such as concurrent chemotherapy or bleeding disorders.

Additional Exclusion Criteria for Healthy Volunteers (HV):

• pregnancy
• sicca symptoms
• HIV, hepatitis B or C infection
• chronic medical illness, other than well-controlled hypertension or hyperlipidemia
• chronic use of medications, with the exception of oral contraception, hormone replacement therapy, aspirin, antihypertensive and antilipemic

• Primary Phenotype: Sjogren's Syndrome
• Salivary Glands
• Exocrine Glands
• Autoimmune Diseases
• Autoantibodies
• Hereditary Autoinflammatory Diseases
• Single-Cell Analysis

• Principal Investigator
  • Blake M. Warner, DDS, PhD, MPH. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
• Co-Investigator
  • Robert Morell, PhD. Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders and National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
• Funding Source
  • 1ZIADE000704. Salivary Disorders Unit and Sjogren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.