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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
Targeted sequencing was performed on blood, tumor, and cell free DNA samples from an FGFR2-fusion positive cholangiocarcinoma patient before and after treatment with an FGFR targeted therapy.
- Study Design:
- Case Set
- Study Type:
- Case Set
- Total number of consented subjects: 1
- Subject Sample Telemetry Report (SSTR)
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Request access via Authorized Access
- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Inclusion Criteria:
- A histologically or cytologically confirmed diagnosis of cancer
- Patients with any malignancy
- Patients must have tumor suitable for research tumor biopsy (as assessed by trained specialists in interventional radiology) and patients are medically fit to undergo a tissue biopsy or surgical procedure to get tumor tissue.
OR
If patients do not have a tumor suitable for biopsy but have another tissue available for molecular evaluation.
OR
Patients are undergoing standard of care surgeries or procedures where fresh specimens will be first used for routine pathologic assessment and only then will leftover tissue be used for research purposes. - Procedure-specific signed informed consent prior to initiation of any study- related procedures
- Women and minorities are included in this protocol
- Patients with multiple malignancies remain eligible
- Patients with an inherited cancer syndrome or a medical history suggestive of an inherited cancer syndrome remain eligible
Autopsy Inclusion Criteria:
- Eligible patients include any patient with metastatic or advanced cancer who is willing to donate their body at time of death for the purposes of advancing cancer research
Exclusion Criteria:
- It is the enrolling study physician's discretion to decide if a patient is not fit enough to undergo tissue biopsy
- Patients who are incarcerated are not eligible to participate
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Targeted Exome Sequencing Illumina MiSeq N/A N/A Targeted RNA Sequencing Illumina MiSeq N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
- Links to Related Genes
- Links to Related Resources
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- BioProject
- PubMed
- Sequence Read Archive
- BioSample
- MeSH
- Gene
- PMC
- Clinical Trials
- Authorized Data Access Requests
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See research articles citing use of the data from this study
- Study Attribution
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Principal Investigator
- Sameek Roychowdhury. Ohio State University, Columbus, OH, USA.
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Funding Source
- American Cancer Society MRSG-12-194-01-TBG. Ohio State University, Columbus, OH, USA.
- Prostate Cancer Foundation. Ohio State University, Columbus, OH USA.
- NHGRI UM1HG006508. Ohio State University, Columbus, OH USA.
- NCI UH2CA202971. Ohio State University, Columbus, OH USA.
- NCI UH2CA216432. Ohio State University, Columbus, OH USA.
- American Lung Association. Ohio State University, Columbus, OH, USA.
- Pelotonia. Ohio State University, Columbus, OH, USA.
- NIH T32 5T32CA009338. Ohio State University, Columbus, OH, USA.
- NIH TL1TR002735. Ohio State University, Columbus, OH, USA.
- Pelotonia Undergraduate Research Fellowship. Ohio State University, Columbus, OH, USA.
- Alex's Lemonade Stand Young Investigator Award. University of Pittsburgh, Pittsburgh, PA, USA.
- Children's Cancer Research Fund Emerging Scientist Grant. University of Pittsburgh, Pittsburgh, PA, USA.
- NIH 2K12HD052892-11A1. University of Pittsburgh, Pittsburgh, PA, USA.
- Pelotonia Post-Doctoral Research Fellowship. Ohio State University, Columbus, OH, USA.
- American Society of Clinical Oncology Young Investigator Award. Ohio State University, Columbus, OH, USA.
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Co-Investigator
- Melanie Krook. Ohio State University, Columbus, OH, USA.
- Alexandria Lenyo. Ohio State University, Columbus, OH, USA.
- Max Wilberding. Ohio State University, Columbus, OH, USA.
- Kelly Bailey. University of Pittsburgh, Pittsburgh, PA, USA.
- Hui-Zi Chen. Ohio State University, Columbus, OH, USA.
- Kelly K. Ciombor. Vanderbilt University Medical Center, Nashville, TN, USA.
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Principal Investigator