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Study Description

The goal of this study was to explore the relationship between genetic variation in the olfactory receptor family and odor perception. 332 subjects rated the intensity and pleasantness of 66 odors at 2 concentrations and 2 solvents. Detection thresholds of 3 odors were also measured. Targeted sequencing was performed on 413 olfactory receptors and approximately 200 olfactory related genes. An association analysis identified regions associated with differences in odor perception.

  • Study Type: Sequencing
  • Number of study subjects that have individual level data available through Authorized Access: 332

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Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

Exclusion criteria for subjects were: allergies to odors or fragrances, a history of nasal illness, upper respiratory infection, seasonal allergy, prior endoscopic surgery on the nose, pre-existing medical condition that has caused a reduced sense of smell such as head injury, cancer therapy, radiation to head and neck, or alcoholism. Pregnant women and children under 18 were excluded from this study.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Targeted Sequencing Illumina Genome Analyzer IIX N/A N/A
Selected publications
Diseases/Traits Related to Study (MESH terms)
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Study Attribution