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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
We generated a collection of patient-derived pancreatic normal and cancer organoids. We performed whole genome sequencing, targeted exome sequencing, and RNA sequencing on organoids as well as matched tumor and normal tissue if available. This dataset is a valuable resource for pancreas cancer researchers, and those looking to compare primary tissue to organoid culture. In our linked publication, we show that pancreatic cancer organoids recapitulate the mutational spectrum of pancreatic cancer. Furthermore, RNA sequencing of organoids demonstrates the presence of both transcriptional subtypes of pancreas cancer.
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Cohort
- Total number of consented subjects: 71
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Consenting pancreatic cancer patients and healthy normal donors were included in this study.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Targeted Exnome Sequencing IDT Integrated DNA Technologies xGen Exome Research Panel v1.0 N/A N/A Performed at New York Genome Center RNA Sequencing Illumina TruSeq RNA Library Preparation Kit V2 N/A N/A Performed at Cold Spring Harbor Laboratory - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Neoplasms
- Carcinoma, Pancreatic Ductal
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- David Tuveson, MD, PhD. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
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Funding Source
- Lustgarten Foundation. Woodbury, NY, USA.
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Principal Investigator