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- Study Description
In order to enhance our understanding of the genetic etiology of breast cancer, this study analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 age-matched population control women, all of whom were age 50 or younger at enrollment. Subjects were recruited from the eight sites, some of which oversampled cases with a personal or family history of breast cancer.
- Study Weblinks:
- Study Design:
- Study Type:
- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Eligible cases were non-Hispanic White women diagnosed with invasive breast cancer when 51 years or younger and not known to carry pathogenic mutations in BRCA1 (GeneID:672) or BRCA2 (GeneID:675). Eligible controls were non-Hispanic White women ages 20 to 51 years without a history of breast cancer.
- Molecular Data
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina Human610-Quad N/A N/A Whole Genome Genotyping Illumina HumanCytoSNP-12v2 N/A N/A Whole Genome Genotyping Illumina HumanExome BeadChip v1.1 N/A N/A
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
- Primary Phenotype: Breast Neoplasms
- Links to Related Genes
- Links to Related Resources
- Authorized Data Access Requests
See research articles citing use of the data from this study
- Study Attribution
- Habibul Ahsan. University of Chicago, Chicago, IL, USA.
- R01CA122171, RC1CA145506, U01CA122171, RC1CA145506, R01CA094069, UM1CA164920, RFA-CA-95-011, UO1CA66572, U19CA148065, R25-CA057699 2T32, and CA057699-26. National Institutes of Health, Bethesda, MD, USA.
- Principal Investigator