Breast Cancer Family Registry Early-onset Breast Cancer GWAS

In order to enhance our understanding of the genetic etiology of breast cancer, this study analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 age-matched population control women, all of whom were age 50 or younger at enrollment. Subjects were recruited from the eight sites, some of which oversampled cases with a personal or family history of breast cancer.

• Study Weblinks:
  • Breast Cancer Family Registry
• Study Design:
  • Case-Control
• Study Type:
  • Case-Control

Eligible cases were non-Hispanic White women diagnosed with invasive breast cancer when 51 years or younger and not known to carry pathogenic mutations in BRCA1 (GeneID:672) or BRCA2 (GeneID:675). Eligible controls were non-Hispanic White women ages 20 to 51 years without a history of breast cancer.

• Primary Phenotype: Breast Neoplasms

• BRCA1
• BRCA2

• BioProject
• PubMed
• MeSH
• Gene
• PMC

• Principal Investigator
  • Habibul Ahsan. University of Chicago, Chicago, IL, USA.
• Funding Source
  • R01CA122171, RC1CA145506, U01CA122171, RC1CA145506, R01CA094069, UM1CA164920, RFA-CA-95-011, UO1CA66572, U19CA148065, R25-CA057699 2T32, and CA057699-26. National Institutes of Health, Bethesda, MD, USA.