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Study Description

In order to enhance our understanding of the genetic etiology of breast cancer, this study analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 age-matched population control women, all of whom were age 50 or younger at enrollment. Subjects were recruited from the eight sites, some of which oversampled cases with a personal or family history of breast cancer.

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Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.

Study Inclusion/Exclusion Criteria

Eligible cases were non-Hispanic White women diagnosed with invasive breast cancer when 51 years or younger and not known to carry pathogenic mutations in BRCA1 (GeneID:672) or BRCA2 (GeneID:675). Eligible controls were non-Hispanic White women ages 20 to 51 years without a history of breast cancer.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina Human610-Quad N/A N/A
Whole Genome Genotyping Illumina HumanCytoSNP-12v2 N/A N/A
Whole Genome Genotyping Illumina HumanExome BeadChip v1.1 N/A N/A
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Diseases/Traits Related to Study (MeSH terms)
Links to Related Genes
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