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- Study Description
Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
This study is part of the NHLBI Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Program. TOPMed is part of a broader Precision Medicine Initiative, which aims to provide disease treatments that are tailored to an individual's unique genes and environment. TOPMed will contribute to this initiative through the integration of whole-genome sequencing (WGS) and other -omics (e.g., metabolic profiles, protein and RNA expression patterns) data with molecular, behavioral, imaging, environmental, and clinical data. In doing so, this program aims to uncover factors that increase or decrease the risk of disease, to identify subtypes of disease, and to develop more targeted and personalized treatments. Two genotype call sets derived from WGS are now available, Freeze 8 (GRCh38) and Freeze 9b (GRCh38), with largely overlapping sample sets. Information about how to identify other TOPMed WGS accessions for cross-study analysis, as well as descriptions of TOPMed methods of data acquisition, data processing and quality control, are provided in the accompanying documents, "TOPMed Whole Genome Sequencing Project - Freeze 8, Phases 1-4" and "TOPMed Whole Genome Sequencing Project - Freeze 9b, Phases 1-4". Please check the study list at the top of each of these methods documents to determine whether it applies to this study accession.
This study contains whole genome sequence data. A case-control sample of individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a multicenter prospective cohort study of 16,415 persons of Cuban, Dominican, Mexican, Puerto Rican, Central American, and South American background (phs000810), was selected for whole genome sequencing, including participants with a history of physician-diagnosed asthma and asthma-free participants.
- Study Weblinks:
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- dbGaP estimated ancestry using GRAF-pop
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Included were self-identified Hispanic/Latino men and women ages 18-74 years, resident in pre-defined geographic areas.
- Study History
At each of four field sites (Miami, FL; Bronx, NY; Chicago, IL; San Diego, CA), 4,000 self-identified Hispanic/Latino men and women ages 18-74 years were recruited and examined. This study is a n=2,150 subsample of the original cohort.
- Selected publications
- Diseases/Traits Related to Study (MeSH terms)
- Links to Related Resources
- Authorized Data Access Requests
See research articles citing use of the data from this study
- Study Attribution
Principal Investigator TOPMed HCHS/SOL
- Eric Boerwinkle. University of Texas Health Science Center at Houston, Houston, TX, USA.
Principal Investigator - HCHS/SOL Coordinating Center
- Jianwen Cai. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Principal Investigators - Field Center
- Robert Kaplan. Albert Einstein College of Medicine, Bronx, NY, USA.
Principal Investigator - Field Center
- Martha Daviglus. Northwestern University, Chicago, IL, USA.
- Neil Schneiderman. University of Miami, Miami, FL, USA.
- Greg Talavera. San Diego State University, San Diego, CA, USA.
HCHS-SOL Funding Source - University of North Carolina Coordinating Center
- N01-HC65233. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
HCHS-SOL Funding Source - University of Miami Field Center
- N01-HC65234. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
HCHS-SOL Funding Source - Bronx Field Center
- N01-HC65235. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
HCHS-SOL Funding Source - Chicago Field Center
- N01-HC65236. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
HCHS-SOL Funding Source - San Diego Field Center
- N01-HC65237. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- Principal Investigator TOPMed HCHS/SOL