NHLBI TOPMed: Women's Health Initiative (WHI)

This study is part of the NHLBI Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Program. TOPMed is part of a broader Precision Medicine Initiative, which aims to provide disease treatments that are tailored to an individual's unique genes and environment. TOPMed will contribute to this initiative through the integration of whole-genome sequencing (WGS) and other -omics (e.g., metabolic profiles, protein and RNA expression patterns) data with molecular, behavioral, imaging, environmental, and clinical data. In doing so, this program aims to uncover factors that increase or decrease the risk of disease, to identify subtypes of disease, and to develop more targeted and personalized treatments. Two genotype call sets derived from WGS are now available, Freeze 8 (GRCh38) and Freeze 9b (GRCh38), with largely overlapping sample sets. Information about how to identify other TOPMed WGS accessions for cross-study analysis, as well as descriptions of TOPMed methods of data acquisition, data processing and quality control, are provided in the accompanying documents, "TOPMed Whole Genome Sequencing Project - Freeze 8, Phases 1-4" and "TOPMed Whole Genome Sequencing Project - Freeze 9b, Phases 1-4". Please check the study list at the top of each of these methods documents to determine whether it applies to this study accession.

This is Whole Genome Sequencing data from the TOPMed participation of the Women's Health Initiative. Approximately 11,100 subjects were involved in this study: approximately 1,100 cases of VTE, 4,000 cases of ischemic stroke, 900 cases of hemorrhagic stroke, and 5,100 controls. Summary level phenotypes for the WHI Cohort study participants can be viewed at the top-level study page phs000200 WHI Cohort. Individual level phenotype data and molecular data for all WHI top-level study and substudies are available by requesting Authorized Access to the WHI Cohort study phs000200.

• Study Weblinks:
  • WHI
  • NHLBI Women's Health Initiative
• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Longitudinal
• dbGaP estimated ancestry using GRAF-pop
• Subject Sample Telemetry Report (SSTR)

The study population consists of approximately 11,100 women who were enrolled in the WHI Clinical Trials and Observational Studies between 1992 and 1998. The inclusion criteria for cases were consent status allowing for data sharing through dbGaP, and incidence case of stroke or venous thromboembolism after enrollment in WHI. Inclusion criteria for controls were consent status allowing for data sharing through dbGaP, and no history of stroke or VTE.

Please see the WHI Top Level study phs000200 for a study history of the WHI study.

• Primary Phenotype: Stroke
• Venous Thromboembolism

• BioProject
• Sequence Read Archive
• BioSample
• MeSH

• Principal Investigator
  • Charles Kooperberg, PhD. Fred Hutchinson Cancer Research Center, Seattle, WA, USA.