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Study Description

We used epigenetic profiling to map active enhancers in the developing human limb and cortex as described in two published studies:

  • Cotney J, Leng J, Yin J, Reilly SK et al. The evolution of lineage-specific regulatory activities in the human embryonic limb. Cell 2013;154(1):185-96.
  • Reilly SK, Yin J, Ayoub AE, Emera D et al. Evolutionary changes in promoter and enhancer activity during human corticogenesis. Science 2015;347(6226):1155-9.

We also used ChIP-seq to map binding sites for the chromatin modifier CHD8 in the developing human brain, as described in one published study:

  • Cotney J, Muhle RA, Sanders SJ, Liu L et al. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun 2015;6:6404.

We are also depositing primary human sequence reads related to processed datasets in the Gene Expression Omnibus under the following accession numbers: GSE42413 (Cotney et al. 2013); GSE63649 (Reilly et al. 2015); GSE57369 (Cotney et al. 2015).

  • Study Type: Control Set
  • Number of study subjects that have individual level data available through Authorized Access: 19

Authorized Access
Publicly Available Data (Public ftp)

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Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
ChIP-Sequencing Illumina HiSeq 2000 N/A N/A
ChIP-Sequencing Illumina HiSeq 2500 N/A N/A
RNA Sequencing Illumina HiSeq 2000 N/A N/A
Selected publications
Diseases/Traits Related to Study (MESH terms)
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Study Attribution