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- Study Description
We used epigenetic profiling to map active enhancers in the developing human limb and cortex as described in two published studies:
- Cotney J, Leng J, Yin J, Reilly SK et al. The evolution of lineage-specific regulatory activities in the human embryonic limb. Cell 2013;154(1):185-96.
- Reilly SK, Yin J, Ayoub AE, Emera D et al. Evolutionary changes in promoter and enhancer activity during human corticogenesis. Science 2015;347(6226):1155-9.
We also used ChIP-seq to map binding sites for the chromatin modifier CHD8 in the developing human brain, as described in one published study:
- Cotney J, Muhle RA, Sanders SJ, Liu L et al. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun 2015;6:6404.
We are also depositing primary human sequence reads related to processed datasets in the Gene Expression Omnibus under the following accession numbers: GSE42413 (Cotney et al. 2013); GSE63649 (Reilly et al. 2015); GSE57369 (Cotney et al. 2015).
- Study Type: Control Set
Number of study subjects that have individual level data available through Authorized Access: 19
- Authorized Access
- Publicly Available Data (Public ftp)
Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.
- Molecular Data
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment ChIP-Sequencing Illumina HiSeq 2000 N/A N/A ChIP-Sequencing Illumina HiSeq 2500 N/A N/A RNA Sequencing Illumina HiSeq 2000 N/A N/A
- Selected publications
- Diseases/Traits Related to Study (MESH terms)
- Links to Related Resources
- Authorized Data Access Requests
- Study Attribution