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- Study Description
Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The Gabriella Miller Kids First Pediatric Research Program (Kids First) is a trans-NIH effort initiated in response to the 2014 Gabriella Miller Kids First Research Act and supported by the NIH Common Fund. This program focuses on gene discovery in pediatric cancers and structural birth defects and the development of the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource).Multi-center, prospective observational cohort study of individuals with congenital heart defects (CHD). Phenotypic data and source DNA derived from 300 probands and their parents, and family of interest collected to investigate relationships between genetic factors and phenotypic and clinical outcomes in patients with CHD.
This Kids First project represents a subset of the PCGC data. Other PCGC data can be accessed through phs001194 and other Kids First data can be accessed through kidsfirstdrc.org.
- Study Weblinks:
- Study Design:
- Study Type:
- Parent-Offspring Trios
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
- Age 0 - 99 years of age
- Males and females
- No ethnic or race restrictions
- Sporadic and familial cases are included
- Pregnant women who have a fetus with diagnosed CHD
- Isolated patent foramen ovale
- Isolated prematurity-associated patent ductus arteriosus
- Lack of consent
- Selected publications
- Diseases/Traits Related to Study (MeSH terms)
- Primary Phenotype: Heart Defects, Congenital
- Links to Related Resources
- Authorized Data Access Requests
See research articles citing use of the data from this study
- Study Attribution
- X01 HL136976. National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- X01 HL132370. National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
- Christine E. Seidman, MD. Harvard Medical School, Boston, MA, USA.
- Funding Sources