Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA)

Asthma is a complex disease where the interplay between genetic factors and environmental exposures influences susceptibility and disease prognosis. Asthmatics of African descent tend to have more severe asthma and more severe clinical symptoms than individuals of European ancestry. Advances in genetic and genomic technologies have revolutionized gene discovery for several complex diseases, but going to the next step in gene discovery for asthma among populations of African descent requires considering unique characteristics of this ethnic group, including adequate sample sizes and population stratification due to (European and African) admixture. Thus far, coverage of common genetic markers both in public databases and commercially available SNP chips has been inadequate to detect and measure genetic associations among African admixed populations. The aim of this study was therefore to catalog genetic diversity in populations of African descent, especially those whose ancestry reflects the African Diaspora in the Americas.

• Study Design:
  • Case-Control
• Study Type:
  • Population Genomics
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 14548
• Subject Sample Telemetry Report (SSTR)

• BioProject
• PubMed
• Sequence Read Archive
• BioSample
• MeSH
• PMC

DNA samples of 1004 individuals of African ancestry were whole genome sequenced. These individuals were selected across North and South America, the Caribbean, and continental Africa, in order to represent a large spectrum of African ancestry. Investigators representing 87 samples from 2 populations (Salvador, Brazil-SCAALA and Pontificia Universidad Católica del Ecuador) requested data not to be shared in dbGaP due to regulatory constraints identified post sequencing.

In September, 2011, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) received support from the National Institutes of Health, National Heart, Lung and Blood Institute, to achieve two broad goals: Discovery of genes conferring risk to asthma among individuals of African ancestry catalog genetic diversity in populations of African descent, especially those whose ancestry reflects the African Diaspora in the Americas. To achieve these goals, CAAPA investigators have generated whole genome sequence data on ~1,000 asthmatics and non-asthmatics, all of African ancestry, selected across North and South America, the Caribbean, and continental Africa, to represent a large spectrum of African ancestry.

• Primary Phenotype: Asthma

• Principal Investigator
  • Kathleen C. Barnes, PhD. University of Colorado, Denver, CO, USA.
• Funding Source
  • R01 HL104608. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.