| Jump to: | Authorized Access | | | Attribution | | | Authorized Requests |
- Study Description
-
Important Links and Information
-
Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The BioImage Study (BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population, NCT00738725), is a prospective, observational study aimed at characterizing subclinical atherosclerosis in U.S. adults (55 to 80 years old) at risk for clinical atherosclerotic cardiovascular disease (PMID: 25790876).
All exome sequencing was performed at the Broad Institute of Harvard and MIT; samples sequence capture was performed using Illumina's ICE Capture reagent and sequencing was performed on an Illumina HiSeq 2000 or 2500.
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 503
- Subject Sample Telemetry Report (SSTR)
-
Request access via Authorized Access
- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
-
- BioProject
- Sequence Read Archive
- MeSH
- Clinical Trials
- Study Inclusion/Exclusion Criteria
We performed a nested case-control experiment for incident cardiovascular events. Cardiovascular events are defined as myocardial infarction, coronary revascularization, or stroke. We included participants who passed the following sample quality control measures: contamination < 5%, missingness < 5%, concordance with genome-wide array data when available, and Ti/Tv, total variants / depth, and F inbreeding coefficient outliers. We also excluded individuals who were genotypically found to be within three degrees of relatedness.
Cases include those who developed cardiovascular events after a median follow-up of 2.7 years. We excluded individuals who had clinical cardiovascular disease at baseline examination. Controls were matched to each case in the matched nested case-control experiment. Controls were matched for age (+/- 2 years), sex, smoking status, and type 2 diabetes status.
- Molecular Data
-
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Exome Sequencing Illumina ICE Capture Reagent N/A N/A Whole Exome Sequencing Illumina HiSeq 2000 N/A N/A Whole Exome Sequencing Illumina HiSeq 2500 N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
-
- Primary Phenotype: Myocardial Infarction
- Authorized Data Access Requests
- Study Attribution
-
-
Principal Investigator
- Stacey Gabriel, PhD. Broad Institute, Boston, MA, USA.
-
Co-Investigator
- Sekar Kathiresan, MD. Broad Institute and Massachusetts General Hospital, Boston, MA, USA.
-
Funding Sources
- National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
-
Principal Investigator