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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The study was initially designed as a longitudinal cohort study of cardiovascular effects of particulate exposure. Participants were boilermaker construction workers who were exposed to particulate matter (PM) component (e.g. a focus on metal constituents) while performing welding, grinding or cutting work in the welding plants. Participants were followed up approximately half a year for a non-work day and a work day from 1999 to 2012, and blood, urine, blood pressure, as well as real-time PM2.5 samples were collected from each participant. In this specific study, we conducted epigenome-wide DNA methylation profiling through Center for Inherited Disease Research (CIDR) services using Illumina Infinium HumanMethylation450, which will give us more compete epigenome-wide coverage. Genome-wide DNA methylation was carried out on paired samples pre- and post-work shift at a welding apprentice school. With transcriptomic and metabolomic data already generated from the same panel study, we will be able to conduct integrative analysis to gain insights into mechanisms of gene-metal interactions and maximize the probability of finding genes functionally relevant to PM-induced adverse cardiovascular outcomes.
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Longitudinal
- Total number of consented subjects: 75
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Inclusion: Active contractor of a local boilermaker union in Quincy, Massachusetts, USA.
Exclusion: Unstable angina symptoms, left bundle branch block, atrial fibrillation, atrial flutter and other rhythms that would compromise interpretation of heart rate variability (HRV), which measures the cardiovascular autonomic responses.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment DNA Methylation Illumina Infinium HumanMethylation450 BeadChip N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Cardiovascular Disease
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- David Christiani, MD, MPH. Harvard T.H. Chan School of Public Health, Boston, MA, USA.
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Genotyping Center
- Johns Hopkins University Center for Inherited Disease Research (CIDR), Baltimore, MD, USA.
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Funding Source
- R01ES009860. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
- HHSN268201200008I, NIH contract "High throughput genotyping for studying the genetic contributions to human disease". National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator