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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The Normative Aging Study (NAS) is a longitudinal study established by the United States Department of Veterans Affairs in 1963. Participants were male residents and free of chronic disease at the time of recruitment. Participants were invited to undergo an in-person examination every 3-5 years. Participants provided information on medical history, lifestyle and demographic factors and underwent a physical examination and laboratory tests, at each visit. Participants provided written informed consent at each visit, and the VA Boston Healthcare System Institutional Review Board approved the study.
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Longitudinal Cohort
- Total number of consented subjects: 657
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
We excluded participants who were non-whites or had missing information on race.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment DNA Methylation Illumina Infinium HumanMethylation450 BeadChip N/A N/A Illumina 450k DNA methylation data were used to calculate DNA methylation age. The calculated age is reported in the data uploaded to dbGaP. - Study History
1963 - Study established
1999 - First blood drawn for EWAS study
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Mortality
- DNA Methylation
- Authorized Data Access Requests
- Study Attribution
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Principal Investigators
- Andrea A. Baccarelli, MD, MPH, PhD. Harvard School of Public Health, Boston, MA, USA.
- Joel Schwartz, PhD. Harvard School of Public Health, Boston, MA, USA.
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Funding Sources
- R01ES015172. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, National Institutes of Health, Bethesda, MD, USA.
- R01ES021733. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, National Institutes of Health, Bethesda, MD, USA.
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Principal Investigators