Pediatric Investigation for Genetic Factors Linked with Renal Progression (PediGFR)

The Pediatric Investigation for Genetic Factors Associated with Renal Progression (PediGFR) (RO1-DK082394) is an international collaborative study among three large prospective cohort studies of children with chronic kidney disease. The participating parent cohort studies are the Chronic Kidney Disease in Children (CKiD), the Effect of Strict Blood Pressure Control and ACE Inhibition on CRF Progression in Pediatric Patients (ESCAPE), and the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study. In these cohorts, pediatric subjects with CKD have been prospectively followed with standardized measurements for renal progression. The dbGaP data upload will utilize the structure of sub-studies to include the genotype and baseline phenotype for the three cohorts, as well as the RBC trait and anemia data for a sub-study under PI Susan Furth: Role of Genetic Variation in the Anemia of Chronic Kidney Disease (K24DK078737).

In brief PediGFR is a prospective study of children with chronic kidney disease (CKD) to determine genetic factors associated with kidney function measured by the estimated glomerular filtration rate (eGFR) by Schwartz equation.

The PediGFR_v2 Cohort is utilized in the following dbGaP sub-studies. To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" section of this top-level study page phs000842 PediGFR_v2 Cohort.

• phs000843 4C
• phs000650 CKiD
• phs000844 ESCAPE

• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Cohort
• Total number of consented subjects: 1828
• Subject Sample Telemetry Report (SSTR)

The PediGFR utilized de-identified data from subjects who had consented for genetic testing, provided a sample of DNA, and who had data available for the renal trait phenotype as well and RBC trait and anemia phenotype. Exclusions are those who did not provide genetic consent, subject IDs whose genotyping did not pass quality control.

The PediGFR study is an international collaborative study designed to determine the gene loci associated with renal progression in children. Genotyping of the US-based CKiD cohort occurred prior to the genotyping of the European cohorts (ESCAPE and 4C). Furthermore, the renal trait phenotype of cystatin C has been assayed for the European cohort.

In November 2013, the genotyping and phenotyping data for the CKiD sub-study were released by dbGaP. Under PI Susan Furth, the ancillary study (K24DK078737) to utilize this genotyping data, The Role of Genetic Variation in the Anemia of Chronic Kidney Disease was included for the data utilized for CKiD.

The genotyping and phenotyping data for the European cohorts (ESCAPE and 4C) are being uploaded to dbGaP as sub-studies. Subsequent upload includes the anemia trait data of the ancillary study (K24DK078737) for ESCAPE/4C cohorts.

• Primary Phenotype: Kidney Diseases
• Renal Insufficiency
• Renal Insufficiency, Chronic

• Principal Investigator
  • Craig Wong MD MPH. University of New Mexico Health Sciences Center and UNM Children's Hospital, NM, USA.
• Funding Source
  • R01DKO82394. National Institutes of Health, Bethesda, MD, USA.