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- Study Description
Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The OPPERA project is investigating effects of genetic, physiological, psychological and clinical factors on the risk of developing painful temporomandibular disorder (TMD). This case-control study is a discovery-phase genome wide association study that aims to identify commonly-occurring genetic variants associated with chronic TMD. It represents the first step in a series of studies that seek to identify the genetic background of TMD.
For related phenotype and targeted genotype data, please see additional studies from the OPPERA project at dbGaP phs000761).
- Study Weblinks:
- Study Design:
- Study Type:
- dbGaP estimated ancestry using GRAF-pop
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Inclusion criteria were all three of:
- Age 18-44 years
- Planning on living in the area for the next two years
- Fluent in written and spoken English
Exclusion criteria were any one of 13 conditions:
- Traumatic facial injury or surgery on the face or jaw within the six months preceding enrollment
- Currently receiving orthodontic treatment
- Pregnant or nursing
- Kidney failure or renal dialysis
- Heart disease or heart failure
- Chronic respiratory disease that is not controlled with medication
- Hypertension that is not controlled with medication
- Epilepsy or medication to control grand mal seizures
- Diabetes that is not controlled with medication or diet
- Drug or alcohol abuse
- Psychiatric disorders or conditions that have required hospitalization
- Chemotherapy or radiation therapy
- Molecular Data
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanOmni2.5 2443179 N/A Plus Exome Data
- Study History
The OPPERA project began in 2006 with enrollment of participants into two studies at four U.S. study sites: Baltimore, MD; Buffalo, NY; Chapel Hill, NC; and Gainesville, FL. In 2012, the National Institute of Dental and Craniofacial Research (NIDCR) awarded funding to support the study for an additional five year period.
- Selected publications
- Diseases/Traits Related to Study (MeSH terms)
- Primary Phenotype: Temporomandibular Joint Disorders
- Chronic Pain
- Links to Related Resources
- Authorized Data Access Requests
See research articles citing use of the data from this study
- Study Attribution
- William Maixner, DDS, PhD. Center for Pain Research and Innovation, Department of Endodontics, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- Gary D. Slade, PhD. Center for Pain Research and Innovation, Department of Dental Ecology, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- Roger B. Fillingim, PhD. Department of Community Dentistry and Behavioral Science, University of Florida, College of Dentistry, Gainesville, FL, USA.
- Richard Ohrbach, DDS, PhD. Department of Oral Diagnostic Sciences, University at Buffalo, Buffalo, NY, USA.
- Joel D. Greenspan, PhD. Department of Neural and Pain Sciences and Brotman Facial Pain Center, University of Maryland Dental School, Baltimore, MD, USA.
Principal Investigator, Data Coordinating Center Director
- Charles Knott, PhD, Data Coordinating Center Director. Battelle Memorial Institute, Durham, NC, USA.
Neurogenomics Core Co-Directors
- Luda Diatchenko, MD, PhD. Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada.
- Bruce S. Weir, PhD. Department of Biostatistics, University of Washington, Seattle, WA, USA.
- Shad B. Smith, PhD. Center for Pain Research and Innovation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- Eric Bair, PhD. Center for Pain Research and Innovation, Department of Biostatistics, Department of Endodontics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- Ronald Dubner, DDS, PhD. Department of Neural and Pain Sciences and Brotman Facial Pain Center, University of Maryland Dental School, Baltimore, MD, USA.
- U01DE017018. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
- Center for Inherited Disease Research (CIDR). Johns Hopkins University, Baltimore, MD, USA.
Genotyping Quality Control
- Genetics Coordinating Center. Department of Biostatistics, University of Washington, WA, USA.
Funding Source for CIDR Genotyping
- HHSN268201200008I, NIH contract "High throughput genotyping for studying the genetic contributions to human disease". National Institutes of Health, Bethesda, MD, USA.
- Co-Program Directors