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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
While many genetic and metabolic studies focus on understanding disease states, this genome wide association study (GWAS) was designed to understand the influence of genetic variants on circulating metabolites and factors in normal, healthy individuals. Over 2500 healthy, ethnically Irish college students attending Trinity College Dublin completed a health and diet questionnaire and provided a non-fasting blood sample to be used for genetic and metabolic analysis. The questionnaire was designed to collect information on age, sex, height, weight, medical conditions, smoking, dietary habits, and consumption of alcohol, fortified foods, and supplements. Extracted DNA was genotyped using the Illumina HumanOmni1-Quad Beadchip. Metabolites were measured using a number of methods and focused on those relevant to the folate/vitamin B12 pathway.
- Study Design:
- Control Set
- Study Type:
- Control Set
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 2408
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Exclusion: At least one grandparent not born in Republic of Ireland or Northern Ireland.
Exclusion: Any major medical health problem.
Inclusion: Ages 18-28.- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033 - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Genome-Wide Association Study
- Body Height
- Body Weight
- Age Distribution
- Sex
- Birth place
- Race
- Cotinine
- Creatinine
- Leukocyte Count
- Erythrocyte Count
- Hemoglobins
- hematocrit
- Mean Corpuscular Volume
- Mean Corpuscular Hemoglobin
- Mean Corpuscular Hemoglobin Concentration
- Platelet Count
- Aspartate aminotransferase
- Alanine Transaminase
- Gamma-glutamyltransferase
- Bilirubin
- Urea
- Uric Acid
- Ferritins
- Vitamin B 12
- Holo transcobalamin II
- Transcobalamin II
- Homocysteine
- Methylmalonic acid
- Cysteine
- Methionine
- Serine
- Glycine
- Cystathionine
- Sarcosine
- Arginine
- Tryptophan
- Kynurenine
- 3-Hydroxykynurenine
- Kynurenic acid
- Xanthurenic acid
- Anthranilic acids
- 3-Hydroxyanthranilic acid
- Neopterin
- Choline
- Betaine
- Dimethylglycine
- Pyridoxal phosphate
- Pyridoxal
- Pyridoxic acid
- Riboflavin
- Flavin mononucleotide
- Flavin-Adenine Dinucleotide
- Authorized Data Access Requests
- Study Attribution
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Co-Investigators
- Lawrence Brody, PhD. National Institutes of Health, Bethesda, MD, USA.
- Anne Molloy, PhD. Trinity College, Dublin, Ireland.
- James Mills, MD. National Institutes of Health, Bethesda, MD, USA.
- Per Magne Ueland, MD. University of Bergen, Norway.
- John Scott, ScD. Trinity College, Dublin, Ireland.
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Genotyping Center
- Johns Hopkins University Center for Inherited Disease Research (CIDR), Baltimore, MD, USA.
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Co-Investigators