Genetic Epidemiology Network of Salt Sensitivity (GenSalt)

The GenSalt study is aimed at identifying novel genes which interact with the effect of dietary sodium and potassium intake or cold pressor on blood pressure.

• Study Design:
  • Interventional
• Study Type:
  • Family
  • Interventional
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 1675
• Subject Sample Telemetry Report (SSTR)

• BioProject
• PubMed
• BioSample
• MeSH
• PMC

Inclusion criteria for proband

• Men or women aged 18-60 years
• Systolic BP 130-160mm Hg and/or diastolic BP 85-100mm Hg
• Both parents (two-generation nuclear family) or at least one parent (three or more generation family) are available and willing to participate in the study
• At least one sibling meets eligibility criteria for participation

Inclusion criteria for siblings/spouses/offspring

• Men or women aged 18-60 years for siblings or aged X16 years for offspring
• Living in the same village with proband

Exclusion criteria for probands/siblings/spouses/offspring

• Current stage-2 hypertension (systolic BP X160mm Hg and/or diastolic BP X100mm Hg)
• Current or recent (less than 1 month before screening visit) use of antihypertensive medications or medications that affect BP
• Secondary hypertension
• History of clinical cardiovascular disease, including myocardial infarction, congestive heart failure, stroke and peripheral arterial disease
• Chronic kidney failure or urinary albumin concentration X20 mg/dl
• Current diabetes (fasting serum glucose X126 mg/dl) or use of insulin or oral hypoglycaemic agents
• Peptic ulcer disease requiring treatment during the previous 2 years
• Liver disease requiring treatment during the previous 2 years
• Currently pregnant women
• Heavy alcohol drinkers (more than 14 drinks per week)
• Currently adhering to a low-sodium diet
• Inability or unwillingness to participate or sign informed consent form

• Primary Phenotype: Arterial Pressure, Mean
• Blood Pressure

• Principal Investigator
  • Jiang He, PhD. Tulane University, New Orleans, LA, USA.
• Funding Sources
  • U01HL072507. National Institutes of Health, Bethesda, MD, USA.
  • R01HL087263. National Institutes of Health, Bethesda, MD, USA.
  • R01HL090682. National Institutes of Health, Bethesda, MD, USA.