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Study Description

We profiled the methylation landscape of ~2100 DNA samples (~1100 cases of colorectal cancer and ~1000 controls) from the Ontario Familial Colon Cancer Registry (OFCCR) using the HumanMethylation450 array from Illumina. DNA was extracted from lymphocyte pellets, except for 99 samples for which DNA was extracted from lymphoblastoid cell lines. Samples were genotyped on the Affymetrix Human Mapping 100k and 500k arrays. The aim the study was to evaluate the interplay between genetic variation and methylation, including long-range epigenetic regulation.

  • Study Weblinks:
  • Study Type:
    • Case-Control
  • dbGaP estimated ancestry using GRAF-pop
  • Number of study subjects that have individual-level data available through Authorized Access:
Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.

Study Inclusion/Exclusion Criteria

The cases and controls used in this study were enrolled in phase I of the Ontario Familial Colon Cancer Registry (OFCCR). Probands were selected from incident colorectal cancer cases identified between July 1,1997 and June 30, 2000 from the population-based Ontario Cancer Registry. Controls were recruited through telephone interviews in randomly selected households in Ontario.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Affymetrix Mapping250K_Nsp 262264 33767 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays
Whole Genome Genotyping Affymetrix Mapping250K_Sty 238304 33766 Affymetrix 500K Set comprises Mapping250K_Nsp and Mapping250K_Sty Arrays
Whole Genome Genotyping Affymetrix Mapping50K_Hind240 57449 33750 Affymetrix 100K Set comprises Mapping50K_Hind240 and Mapping50K_Xba240 Arrays
Whole Genome Genotyping Affymetrix Mapping50K_Xba240 58960 33751 Affymetrix 100K Set comprises Mapping50K_Hind240 and Mapping50K_Xba240 Arrays
Methylation Illumina Human Methylation 450 v.1.1 N/A N/A
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