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Study Description

We profiled the miRNA contents from cerebrospinal fluid and serum (using next generation sequencing) from postmortem patients diagnosed with Alzheimer's or Parkinson's disease, and neurologically normal controls. All biofluids were cell-free and patient matched, there was one cerebrospinal fluid and one serum sample from each of 70 patients with Alzheimer's disease, 67 patients with Parkinson's disease and 78 age-similar controls. We correlated the miRNA changes with measurements of neuropathology such as plaques, tangles and Lewy bodies.

  • Study Weblinks: michaeljfox; tgen
  • Study Type: Case-Control
  • Number of study subjects that have individual level data available through Authorized Access: 211

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Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

For inclusion in the study, the participants had to be diagnosed with Alzheimer's disease or Parkinson's disease based on postmortem neuropathological criteria or to be neuropathologically normal.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
MicroRNA Sequencing Illumina TruSeq Small RNA Sample Prep Kit N/A N/A
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Diseases/Traits Related to Study (MESH terms)
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