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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
This sub-study phs000650 CKiD contains genotype and selected phenotype of subjects available from the phs000650 study. Summary level phenotypes for the NIDDK PediGFR_v2 Cohort study participants can be viewed at the top-level study page phs000842 PediGFR_v2 Cohort. Individual level phenotype data and molecular data for all PediGFR_v2 Cohort top-level study and sub-study are available by requesting Authorized Access to the NIDDK PediGFR_v2 Cohort phs000842 study.
The Pediatric Investigation for Genetic Factors Associated with Renal Progression (PediGFR) (RO1-DK082394) is an international collaborative study among three large prospective cohort studies of children with chronic kidney disease. The participating parent cohort studies are the Chronic Kidney Disease in Children (CKiD), the Effect of Strict Blood Pressure Control and ACE Inhibition on CRF Progression in Pediatric Patients (ESCAPE), and the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study. In these cohorts, pediatric subjects with CKD have been prospectively followed with standardized measurements for renal progression. The current version of the upload includes the genotype and baseline phenotype for the CKiD cohort. In brief the CKiD study is a prospective study of children with chronic kidney disease (CKD) between the ages of 1 year to 16 years of age and an estimated glomerular filtration rate (eGFR) by Schwartz equation between 30 and 75 ml/min per 1.73m2. Included in the upload is the second subcohort of CKiD study.
- Study Design:
- Prospective Longitudinal Cohort
- Study Type:
- Cohort
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 842
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
The PediGFR utilized de-identified data from subjects who had consented for genetic testing, provided a sample of DNA, and who had data available for the renal trait phenotype as well and RBC trait and anemia phenotype. Exclusions are those who did not provide genetic consent, subject IDs whose genotyping did not pass quality control.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina HumanOmni2.5-Quad N/A N/A - Study History
The PediGFR study is an international collaborative study designed to determine the gene loci associated with renal progression in children. Genotyping of the US-based CKiD cohort occurred prior to the genotyping of the European cohorts (ESCAPE and 4C). Furthermore, the renal trait phenotype of cystatin C has been assayed for the European cohort.
In November 2013, the genotyping and phenotyping data for the CKiD sub-study were released by dbGaP. Under PI Susan Furth, the ancillary study (K24DK078737) to utilize this genotyping data, The Role of Genetic Variation in the Anemia of Chronic Kidney Disease was included for the data utilized for CKiD.
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Kidney Diseases
- Renal Insufficiency
- Renal Insufficiency, Chronic
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- Craig Wong MD MPH. University of New Mexico Health Sciences Center and UNM Children's Hospital, NM, USA.
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Funding Source
- R01DKO82394. National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator