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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
Autism is a common disorder whose causes are poorly understood. Both genetic and environmental influences are thought to act together causing autism. Epigenetics is an area that bridges genetic and environmental influencing and commonly is studied by examining dynamic methylation changes to the DNA. We have screened a total of 78 autistic boys and their fathers by this method in 807 genes and find 116 methylation changes that together can correctly identify nearly 80% of the affected boys from their fathers. We propose to confirm these exciting data in a much larger set of genes in 1,200 autistic boys and their families, including unaffected brothers. These data not only could provide new insight into the causes of autism but could also result in a screening test for autism.
- Study Weblinks:
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- Total number of consented subjects: 820
- Subject Sample Telemetry Report (SSTR)
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- Publicly Available Data
- Link to other NCBI resources related to this study
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment DNA Methylation Illumina 450K Infinium Methylation N/A N/A - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Autistic Disorder
- Autism
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- Stephen Warren, PhD. Emory University, Atlanta, GA, USA.
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Funding Source
- R01MH089606. National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator