My NCBI Sign In
Jump to: Authorized Access | Attribution | Authorized Requests

Study Description

This sub-study phs000613 CARDIA_CARe contains genotype of subjects available from the phs000613 study. Summary level phenotypes for the NHLBI CARDIA Cohort study participants can be viewed at the top-level study page phs000285 CARDIA_v3 Cohort. Individual level phenotype data and molecular data for all CARDIA Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI CARDIA Cohort phs000285 study.

The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining the development and determinants of clinical and subclinical cardiovascular disease and its risk factors. It began in 1985 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be approximately the same number of people in subgroups of race, gender, education (high school or less and more than high school) and age (18-24 and 25-30) in each of 4 centers: Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), and 2005-2006 (Year 20). A majority of the group has been examined at each of the follow-up examinations (90%, 86%, 81%, 79%, 74%, and 72%, respectively).

While the specific aims of each examination have varied, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids, and glucose. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5 and 10, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20.

NHLBI Candidate-gene Association Resource. The NHLBI initiated the Candidate gene Association Resource (CARe) to create a shared genotype/phenotype resource for analyses of the association of genotypes with phenotypes relevant to the mission of the NHLBI. The resource comprises nine cohort studies funded by the NHLBI including: Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Cleveland Family Study (CFS), Coronary Artery Risk Development in Young Adults (CARDIA), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Multi-Ethnic Study of Atherosclerosis (MESA), and the Sleep Heart Health Study (SHHS). A database of genotype and phenotype data was created that includes records for approximately 41,000 study participants with approximately 50,000 SNPs from more than 2,000 selected candidate genes. In addition, a genome wide association study using a 1,000K SNP Chip was conducted on approximately 8,900 African American participants drawn from five CARe cohorts: ARIC, CARDIA, CFS, JHS, and MESA. Data from individual cohorts is available to approved investigators through dbGaP.

Some relevant CARe publications
CARe Study: PMID 20400780
CVD Chip Design: PMID 18974833

  • Study Weblink: CARDIA
  • Study Type: Longitudinal
  • Number of study subjects that have individual level data available through Authorized Access: 3299

Authorized Access
Publicly Available Data (Public ftp)

Note: Access to publicly available data is available on the public ftp site for study phs000285.v3.p2.

Study Inclusion/Exclusion Criteria

African-Americans and Whites aged 18-30 at the baseline examination

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Affymetrix AFFY_6.0 934940 52074
Targeted Region Genotyping Illumina CVDSNP55v1_A 49094 1050734
Study History

The cohort has been examined at 7 clinic visits, with an 8th visit scheduled.

Baseline Examination: 1985-1986
Exam 2: 1987-1988
Exam 3: 1990-1991
Exam 4: 1992-1993
Exam 5: 1995-1996
Exam 6: 2000-2001
Exam 7: 2005-2006
Exam 8: (ongoing) 2010-2011

Selected publications
Diseases/Traits Related to Study (MESH terms)
Links to Related Resources
Authorized Data Access Requests
Study Attribution