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- Study Description
This sub-study phs000610 RM_Epigenomics_Broad_Alz contains molecular data of subjects available from the phs000610 study. Summary level phenotypes for the NADI Roadmap Epigenomics Broad cohort study participants can be viewed at the top-level study page phs000700 Roadmap Epigenomics Broad cohort. Individual level phenotype data and molecular data for all Roadmap Epigenomics Broad cohort top-level study and sub-study are available by requesting Authorized Access to the NADI Roadmap Epigenomics Broad cohort phs000700 study.
Post-mortem brain samples were obtained from participants in the Rush Medical Center Religious Order Study; donors were selected who were classified as having no evidence of Alzheimer's disease upon demise. Brain samples were dissected to sub-anatomical regions and preserved by rapid freezing. Tissues were subject to chromatin preparation for ChIP-Seq, to RNA isolation for RNASeq, and to DNA isolation and bisulfite conversion for whole genome shotgun bisulfite sequencing.
- Study Design:
- Study Type:
- Number of study subjects that have individual-level data available through Authorized Access:
- Study Design:
- Authorized Access
- Publicly Available Data (Public ftp)
- Study Inclusion/Exclusion Criteria
Inclusion by the Roadmap Epigenomics Program was limited to donors having no evidence of Alzheimer's disease upon demise.
- Molecular Data
Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment ChIP-Sequencing Illumina HiSeq 2000 N/A N/A Whole Genome Bisulfite Shotgun Sequencing Illumina HiSeq 2000 N/A N/A RNA Sequencing Illumina HiSeq 2000 N/A N/A Multiplexed Reduced Representation Bisulfite Sequencing Illumina HiSeq 2000 N/A N/A
- Selected publications
- Diseases/Traits Related to Study (MeSH terms)
- Primary Phenotype: Nervous System Diseases
- Links to Related Resources
- Authorized Data Access Requests
See research articles citing use of the data from this study
- Study Attribution