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Study Description

This sub-study phs000610 RM_Epigenomics_Broad_Alz contains molecular data of subjects available from the phs000610 study. Summary level phenotypes for the NADI Roadmap Epigenomics Broad cohort study participants can be viewed at the top-level study page phs000700 Roadmap Epigenomics Broad cohort. Individual level phenotype data and molecular data for all Roadmap Epigenomics Broad cohort top-level study and sub-study are available by requesting Authorized Access to the NADI Roadmap Epigenomics Broad cohort phs000700 study.

Post-mortem brain samples were obtained from participants in the Rush Medical Center Religious Order Study; donors were selected who were classified as having no evidence of Alzheimer's disease upon demise. Brain samples were dissected to sub-anatomical regions and preserved by rapid freezing. Tissues were subject to chromatin preparation for ChIP-Seq, to RNA isolation for RNASeq, and to DNA isolation and bisulfite conversion for whole genome shotgun bisulfite sequencing.

  • Study Design:
    • Methods
  • Study Type:
    • Epigenetics
  • Number of study subjects that have individual-level data available through Authorized Access:
Authorized Access
Publicly Available Data (Public ftp)

Note: Access to publicly available data is available on the public ftp site for study phs000700.v2.p1

Study Inclusion/Exclusion Criteria

Inclusion by the Roadmap Epigenomics Program was limited to donors having no evidence of Alzheimer's disease upon demise.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
ChIP-Sequencing Illumina HiSeq 2000 N/A N/A
Whole Genome Bisulfite Shotgun Sequencing Illumina HiSeq 2000 N/A N/A
RNA Sequencing Illumina HiSeq 2000 N/A N/A
Multiplexed Reduced Representation Bisulfite Sequencing Illumina HiSeq 2000 N/A N/A
Selected publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Resources
Authorized Data Access Requests
See research articles citing use of the data from this study
Study Attribution
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