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Study Description

The Detroit Neighborhood Health Study (DNHS) is a prospective, representative longitudinal cohort study of predominantly African American adults living in Detroit, Michigan. The overall goal of the DNHS is to identify how genetic variation, lifetime experience of stressful and traumatic events, and features of the neighborhood environment predict psychopathology and behavior. Cohort participants were selected with a dual-frame probability design, using telephone numbers obtained from the U.S. Postal Service Delivery Sequence Files as well as a listed-assisted random-digit-dial frame. Individuals without listed landlines or telephones and individuals with only a cell phone listed were invited to participate through a postal mail effort. Participants completed a 40 minute, structured telephone interview annually between 2008-2012 to assess perceptions of participants' neighborhoods, mental and physical health status, social support, exposure to traumatic events, and alcohol and tobacco use; each participant was compensated $25USD. All survey participants were offered the opportunity to provide a specimen (venipuncture, blood spot, or saliva) for immune and inflammatory marker testing as well as genetic testing of DNA. Participants received an additional $25USD if they elected to give a sample. Informed consent was obtained at the beginning of each interview and again at specimen collection. The Institutional Review Board of the University of Michigan reviewed and approved the study protocol. The DNHS submission to dbGaP includes phenotype data from all five survey waves (n=856), all available GWAS data for participants who completed wave 4 (n=507), and methylation data for wave 1, wave 2, wave 4, and wave 5 participants (n = 456).

Authorized Access
Publicly Available Data (Public ftp)
Study Inclusion/Exclusion Criteria

In 2008, was resident of Detroit, Michigan, and aged 18 years or older.

Study History

Submission to dbGaP includes phenotype data collected from all five waves of the DNHS (years 2008-2013).

Funding for data collection with PhenX variables has been provided by the NHGRI PhenX RISING program.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Resources
Authorized Data Access Requests
See research articles citing use of the data from this study
Study Attribution
  • Principal Investigator
    • Allison E. Aiello, PhD, MS. University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Co-Investigator
    • Monica Uddin, PhD. University of South Florida College of Public Health, Tampa, FL, USA.
  • Funding Source
    • R01 DA022720. National Institutes of Health, Bethesda, MD, USA.
    • R01 MD011728. National Institutes of Health, Bethesda, MD, USA.