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Study Description

The Chronic Renal Insufficiency Cohort (CRIC study) was established in 2001 by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) to improve the understanding of the relationship between chronic kidney disease and cardiovascular disease. The goals of the CRIC Study are to examine risk factors for progression of chronic kidney disease and cardiovascular disease among patients with chronic kidney disease and to develop predictive models to identify high-risk subgroups, informing future treatment trials and increasing application of available preventive therapies.

  • Study Weblinks:
  • Study Design:
    • Case Set
  • Study Type:
    • Cohort
  • dbGaP estimated ancestry using GRAF-pop
Authorized Access
Publicly Available Data (Public ftp)
Study Inclusion/Exclusion Criteria

Participants are no longer being enrolled in the study. The following Inclusion/Exclusion Criteria were followed at the time of participant recruitment.

Inclusion: 21 to 74 years; Age Based eGFR: 21-44 years 20-70 ml/min/1/73m2), 45-64 years 20-60 ml/min/1/73m2, 65-74 years 20-50 ml/min/1/73m2.

Exclusion: Institutionalized, unable or unwilling to provide informed consent, participant appears unlikely or unable to participate in the required study procedures as assessed by the investigator, study coordinator or designee, NYHA Class III or IV heart failure at baseline, known cirrhosis based on patient self-report, known HIV infection and/or AIDS based on patient self-report, present participation in the AASK Cohort Study, pregnant women.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033
Study History

2001: design of the study began
2004-2008: recruitment of participants conducted resulting in over 3000 enrolled participants
2008: study funding extended for 5 years
2008: phase 2 of the study began
2012: application for phase 3 funding in development

Selected publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Resources
Authorized Data Access Requests
See research articles citing use of the data from this study
Study Attribution