Cebu Longitudinal Health and Nutrition Survey (CLHNS)

Conducted by a team of researchers from the United States and the Philippines, the Cebu Longitudinal Health and Nutrition Survey is part of an ongoing study of a cohort of Filipino women who gave birth between May 1, 1983, and April 30, 1984. The cohort of children born during that period, their mothers, other caretakers, and selected siblings have been followed through subsequent surveys conducted in 1991-92, 1994, 1999, 2002, and 2005. Current research is focused on the long-term effects of prenatal and early childhood nutrition and health on later adult outcomes, including development of chronic disease risk factors. Fasting plasma samples collected in 2005 were used to measure several biomarkers related to cardiovascular disease risk. Genome-wide genotyping was performed in the mothers.

• Study Weblinks:
  • Cebu Longitudinal Health and Nutrition Survey
• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Cohort
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 1799
• Subject Sample Telemetry Report (SSTR)

A single stage cluster sampling procedure was used to randomly select 33 communities or barangays (17 urban, 16 rural) from the Metropolitan Cebu area. The barangays, which contained about 28,000 households, were completely surveyed in late 1982 and again in early 1983 to locate all pregnant women. Women of the selected barangays who gave birth between May 1, 1983, and April 30, 1984, are included in the sample. A baseline interview was conducted among 3,327 women during the 6th to 7th month of pregnancy. Subsequent surveys began immediately after birth. Some individuals were lost to follow-up prior to collection of DNA in 2005. One member of each known or estimated first-degree relative pair was excluded, leaving a total of 1,799 samples for genetic analysis.

Further description of the cohort is available on-line (PMID: 20507864).

• Primary Phenotype: Maternal Nutritional Physiological Phenomena

• Principal Investigator
  • Linda S. Adair, PhD. Department of Nutrition, and Fellow, Carolina Population Center, University of North Carolina, USA.
• Principal Investigator - Genetics
  • Karen L. Mohlke, PhD. Department of Genetics, University of North Carolina, USA.
• Co-Investigator
  • Barry M. Popkin, PhD. Department of Nutrition, and Fellow, Carolina Population Center, University of North Carolina, USA.
  • Kenneth Bollen, PhD. Department of Sociology and Fellow, Carolina Population Center, University of North Carolina, USA.
  • David K. Guilkey, PhD. Department of Economics and Fellow, Carolina Population Center, University of North Carolina, USA.
  • Socorro Gultiano, PhD. Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
  • Judith Borja, PhD. Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
  • Alan Feranil, PhD. Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
  • Josephine Avila, MA. Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
  • Nanette R. Lee, PhD. Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines.
  • Christopher Kuzawa, PhD. Department of Anthropology; Laboratory for Human Biology Research, Northwestern University, USA.
  • Thomas McDade, PhD. Department of Anthropology; Director, Laboratory for Human Biology Research, Northwestern University, USA.
  • Michelle Hindin, PhD, MHS. Department of Population, Family and Reproductive Health, Bloomberg School of Public Health, Johns Hopkins University, USA.
• Funding Source
  • R01-HD19983A. National Institutes of Health, Bethesda, MD, USA.
  • R01-HD18880. National Institutes of Health, Bethesda, MD, USA.
  • R01-HD28076. National Institutes of Health, Bethesda, MD, USA.
  • R01-HD23182. National Institutes of Health, Bethesda, MD, USA.
  • R01-TW05596. National Institutes of Health, Bethesda, MD, USA.
  • R01-HL085144. National Institutes of Health, Bethesda, MD, USA.
  • R01-DK078150. National Institutes of Health, Bethesda, MD, USA.
  • R01-HD054501. National Institutes of Health, Bethesda, MD, USA.
  • R03-TW008133. National Institutes of Health, Bethesda, MD, USA.
  • R01-AG039443. National Institutes of Health, Bethesda, MD, USA.