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Study Description

Conducted by a team of researchers from the United States and the Philippines, the Cebu Longitudinal Health and Nutrition Survey is part of an ongoing study of a cohort of Filipino women who gave birth between May 1, 1983, and April 30, 1984. The cohort of children born during that period, their mothers, other caretakers, and selected siblings have been followed through subsequent surveys conducted in 1991-92, 1994, 1999, 2002, and 2005. Current research is focused on the long-term effects of prenatal and early childhood nutrition and health on later adult outcomes, including development of chronic disease risk factors. Fasting plasma samples collected in 2005 were used to measure several biomarkers related to cardiovascular disease risk. Genome-wide genotyping was performed in the mothers.

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Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.

Study Inclusion/Exclusion Criteria

A single stage cluster sampling procedure was used to randomly select 33 communities or barangays (17 urban, 16 rural) from the Metropolitan Cebu area. The barangays, which contained about 28,000 households, were completely surveyed in late 1982 and again in early 1983 to locate all pregnant women. Women of the selected barangays who gave birth between May 1, 1983, and April 30, 1984, are included in the sample. A baseline interview was conducted among 3,327 women during the 6th to 7th month of pregnancy. Subsequent surveys began immediately after birth. Some individuals were lost to follow-up prior to collection of DNA in 2005. One member of each known or estimated first-degree relative pair was excluded, leaving a total of 1,799 samples for genetic analysis.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Affymetrix GenomeWideSNP_5 440792 1049350
Study History

Further description of the cohort is available on-line (PMID: 20507864).

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Diseases/Traits Related to Study (MeSH terms)
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