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Study Description

Study to evaluate the molecular genetics of ccRCC through integrative analyses of tumors and tumorgrafts using multiple platforms in clinically annotated samples. Genome and exome data for patients giving consent to have the information available on a public, secure, database is being submitted.

Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Exome Sequencing Illumina Genome Analyzer II N/A N/A
Whole Genome Genotyping Affymetrix AFFY_6.0 934940 52074
Gene Expression Affymetrix Human Genome U133 Plus 2.0 Array N/A N/A
Study History

  1. Whole-Genome sequencing of a ccRCC tumor/normal pair
  2. Exome Sequencing for a ccRCC tumor/normal pair
  3. Exome Sequencing for a ccRCC tumor/metastasis/normal trio

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • James Brugarolas, MD, PhD. UT Southwestern Medical Center, Dallas, TX, USA.
  • Co-Investigator
    • Samuel Peña-Llopis, PhD. UT Southwestern Medical Center, Dallas, TX, USA.
  • Funding Sources
    • 2007062. Clinical Scientist Development Award from the Doris Duke Charitable Foundation, New York, NY, USA.
    • RP101075. Cancer Prevention and Research Institute of Texas (CPRIT), Austin, TX, USA.
    • Virginia Murchison Linthicum Endowment Scholar, UT Southwestern Medical Center, Dallas, TX, USA.