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Study Description

Schizophrenia is characterized by high heritability (~80%), yet the identification of susceptibility genes has proven extremely challenging. The Ashkenazi Jewish population, derived from a limited number of founders, may be enriched for a subset of susceptibility alleles, which may also have higher odds ratios than those detected by previous studies. GWAS was conducted in a large Ashkenazi case-control cohort, derived from the Hebrew University Genetic Resource, using the Illumina HumanOmni1-Quad BeadChip.

  • Study Type: Case-Control
  • dbGaP estimated ancestry components using GRAF-pop
  • Number of study subjects that have individual level data available through Authorized Access: 3096

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033
Study History

Inclusion criteria for all subjects: self-identified 4 grandparents of Ashkenazi Jewish heritage Inclusion criteria for cases: hospitalized inpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder.

Exclusion criteria for cases: subjects diagnosed with at least one of the following disorders: psychotic disorder due to a general medical condition, substance-induced psychotic disorder, or any Cluster A (schizotypal, schizoid, or paranoid) personality disorder. Exclusion criteria for controls: report of any chronic disease or taking any medication at the time of blood draw.

Selected publications
Diseases/Traits Related to Study (MESH terms)
Links to Related Resources
Authorized Data Access Requests
Study Attribution