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Study Description

In this second study version, we report a genome-wide association study of IgA nephropathy performed in individuals of European ancestry (US and Italian cohorts), followed by a meta-analysis with the existing GWAS cohorts (Han Chinese [study version 1] and French cohorts). Genomic DNA was extracted from whole blood and genotyped with the HumanHap550-2v3, Human610-Quadv1and HumanOmni1-Quad_v1 platforms. This GWAS also utilized pre-genotyped population controls from other studies.

  • Study Type: Case-Control
  • dbGaP estimated ancestry components using GRAF-pop
  • Number of study subjects that have individual level data available through Authorized Access: 3615

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

The inclusion criterion for cases was confirmation of affected status by renal biopsy.

Control participants were healthy blood donors.

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina Human610_Quadv1_B 601273 1048904
Whole Genome Genotyping Illumina HumanOmni1-Quad_v1-0_B 1051295 1049033
Study History

2012 - dbGaP data release: Participants of Chinese Han Ancestry

2015 - dbGaP data release: Participants of European Ancestry

Selected publications
Diseases/Traits Related to Study (MESH terms)
  • Primary Phenotype: Glomerulonephritis, IGA
Authorized Data Access Requests
Study Attribution