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Study Description

A collection of patients with type-2 diabetes was collected at the Joslin Diabetes Center. Patients were categorized to a group of cases with diabetic nephropathy, and a group of controls with normoalbuminuria. From these groups, 173 cases and 177 controls were randomly selected for a genome-wide association study.

  • Study Type: Case-Control
  • Number of study subjects that have individual level data available through Authorized Access: 350

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. If available, the site also contains data dictionaries, variable summaries, documents, and truncated analyses.

Study Inclusion/Exclusion Criteria

Inclusion as Participant:

  1. Self-reported diabetes mellitus (DM)
  2. Age at diagnosis of DM greater than 40, or age at diagnosis between 20 and 40 and no insulin treatment, or age at diagnosis between 20 and 40 and initiation of insulin treatment more than 2 years after diagnosis of DM
  3. Absence of non-diabetic kidney disease

Inclusion as Control:

  1. Normoalbuminuria
  2. CKD Stage 1 or 2
  3. Duration of DM of at least 3 years
  4. Hemoglobin A1c of at least 6

Inclusion as Case:

  1. Proteinuria or End-Stage Renal Disease or Microalbuminuria and CKD Stage 4 or 5

Molecular Data
TypeSourcePlatformNumber of Oligos/SNPsSNP Batch IdComment
Whole Genome Genotyping Illumina HumanCNV370v1 370404 1047132
Selected publications
Diseases/Traits Related to Study (MESH terms)
Links to Related Resources
Authorized Data Access Requests
Study Attribution