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Substudies
phs000090.v6.p1 : GENEVA: The Atherosclerosis Risk in Communities (ARIC) Study
phs000223.v6.p1 : PAGE: CALiCo: Atherosclerosis Risk in Communities (ARIC)
phs000398.v6.p1 : NHLBI GO-ESP: Heart Cohorts Exome Sequencing Project (ARIC)
phs000557.v5.p1 : NHLBI ARIC Candidate Gene Association Resource (CARe)
phs000668.v4.p1 : Building on GWAS: the U.S. CHARGE consortium - Sequencing (CHARGE-S): ARIC
phs000860.v4.p1 : MIchigan-CORnell-TEXas (MICORTEX)
phs001536.v1.p1 : Center for Common Disease Genomics: ARIC

Study Description

The Atherosclerosis Risk in Communities (ARIC) Study, sponsored by the National Heart, Lung and Blood Institute (NHLBI), is a prospective epidemiologic study conducted in four U.S. communities. The four communities are Forsyth County, NC; Jackson, MS; the northwest suburbs of Minneapolis, MN; and Washington County, MD. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, gender, location, and date.

ARIC includes two parts: the Cohort Component and the Community Surveillance Component. The Cohort Component began in 1987, and each ARIC field center randomly selected and recruited a cohort sample of approximately 4,000 individuals aged 45-64 from a defined population in their community. A total of 15,792 participants received an extensive examination, including medical, social, and demographic data. These participants were examined with the baseline visit occurring in 1987-89, the second visit in 1990-92, the third visit in 1993-95, the fourth visit in 1996-98, and the fifth visit in 2011-13. Follow-up occurs yearly by telephone to maintain contact with participants and to assess health status of the cohort.

In the Community Surveillance Component, these four communities were investigated to determine the community-wide occurrence of hospitalized myocardial infarction and coronary heart disease deaths in men and women aged 35-84 years. Hospitalized stroke is investigated in cohort participants only. Starting in 2006, the study conducted community surveillance of inpatient (ages 55 years and older) and outpatient heart failure (ages 65 years and older) for heart failure events beginning in 2005. Community Surveillance for non-cohorts ended in event year 2014.

ARIC is currently funded through October 31, 2021.

The ARIC Cohort is utilized in the following dbGaP sub-studies. To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" section of this top-level study page phs000280 ARIC Cohort.

Authorized Access
Publicly Available Data (Public ftp)

Connect to the public download site. The site contains release notes and manifests. The site also contains data dictionaries, variable summaries, documents, and truncated analyses, whenever available.

Study Inclusion/Exclusion Criteria

Aged 45-64 at baseline

Study History

The cohort was examined at 5 clinic visits:

Visit 1: 1987-89

Visit 2: 1990-92

Visit 3: 1993-95

Visit 4: 1996-98

Visit 5: 2011-13

Selected publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Resources
Authorized Data Access Requests
Study Attribution