Population Architecture using Genomics and Epidemiology (PAGE): Causal Variants Across the Life Course (CALiCo): Coronary Artery Risk Development in Young Adults (CARDIA)

This sub-study phs000236 PAGE CALiCo CARDIA contains genotype derived from sequence data and selected phenotype of subjects available from the phs000236 study. Summary level phenotypes for the NHLBI CARDIA Cohort study participants can be viewed at the top-level study page phs000285 CARDIA Cohort. Individual level phenotype data and molecular data for all CARDIA Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI CARDIA Cohort phs000285 study.

CALiCo CARDIA
The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining how heart disease develops in adults. It began in 1986 with a group of 5115 black and white men and women aged 18-30 years. The participants were selected so that there would be approximately the same number of people in subgroups of race, gender, education (high school or less and more than high school) and age (18-24 and 25-30) in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. These same participants were asked to participate in follow-up examinations during 1987-1988 (Year 2), 1990-1991 (Year 5), 1992-1993 (Year 7), 1995-1996 (Year 10), 2000-2001 (Year 15), and 2005-2006 (Year 20). A majority of the group has been examined at each of the follow-up examinations (90%, 86%, 81%, 79%, 74%, and 72%, respectively).

While the specifics of each examination has differed somewhat, data have been collected on a variety of factors believed to be related to heart disease. These include conditions with clear links to heart disease such as blood pressure, cholesterol and other lipids. Data have also been collected on physical measurements such as weight and skinfold fat as well as lifestyle factors such as substance use (tobacco and alcohol), dietary and exercise patterns, behavioral and psychological variables, medical and family history, and other chemistries (e.g., insulin and glucose). In addition, subclinical atherosclerosis was measured via echocardiography during Years 5 and 10, computed tomography during Years 15 and 20, and carotid ultrasound during Year 20. A detailed description of the study and results from the first examination are summarized in Cutter et al (Controlled Clinical Trials, Volume 12, Number 1 [supplement], pages 1S-77S, 1991).

This study is part of the Population Architecture using Genomics and Epidemiology (PAGE) study phs000356.

• Study Weblinks:
  • Population Architecture using Genomics and Epidemiology (PAGE)
  • CARDIA
• Study Design:
  • Prospective Longitudinal Cohort
• Study Type:
  • Longitudinal
• dbGaP estimated ancestry using GRAF-pop
• Total number of consented subjects: 3595
• Subject Sample Telemetry Report (SSTR)

• Clinical Trials
  • NCT00005130

The initial examination included 5,115 participants selectively recruited to represent proportionate racial, gender, age, and education groups from 4 communities: Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA. Participants from the Birmingham, Chicago, and Minneapolis centers were recruited from the total community or from selected census tracts. Participants from the Oakland center were randomly recruited from the Kaiser-Permanente health plan membership.

5,115 young adults aged 18 to 30 at baseline (1985-86) recruited from four field centers in Birmingham, AL, Chicago, IL, Minneapolis, MN, and Oakland, CA, equally distributed by age group, sex, race (black and white), and education (≤ high school, > high school). There are seven exams-years 0, 2, 5, 7, 10, 15, 20 (Year 25 scheduled for 2010).

• Primary Phenotype: Cardiovascular Diseases
• Type 2 Diabetes Mellitus
• Obesity
• Cholesterol, HDL
• Cholesterol, LDL
• Coronary Disease
• Triglycerides
• Myocardial Infarction
• C-Reactive Protein
• Gout
• Uric Acid
• Kidney
• Stroke
• Hypertension
• Respiratory Tract Diseases

• Principal Investigator
  • Kari North. University of North Carolina, Chapel Hill, NC, USA.
  • Gerardo Heiss. University of North Carolina, Chapel Hill, NC, USA.
• Institute
  • National Human Genome Research Institute.
• Funding Source - Genotyping and Analysis
  • U01HG007416. National Institutes of Health, Bethesda, MD, USA.
  • U01HG004803. National Institutes of Health, Bethesda, MD, USA.
• Funding Source
  • N01-HC-95095. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-48047. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-48048. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-48049. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-48050. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-45134. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-05187. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • N01-HC-45205. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.