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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
Generalized vitiligo is an autoimmune disease in which melanocyte loss results in patchy depigmentation of skin and hair. For this third GWAS of generalized vitiligo, SNPs were genotyped in 1,059 generalized vitiligo cases of European-derived white (EUR) ancestry using the Illumina Human OmniExpress BeadChip array. The data were combined with those of Phase 1 and Phase 2 to provide at least 85% power to detect associations with OR > 1.22 at genome-wide significance (P = 5 x 10-8) for MAF > 0.25.
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- Cohort
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 2857
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
Cases:
Inclusion: EUR; must meet strict clinical diagnostic criteria for generalized vitiligo
Exclusion: Non-EUR, must not have any form of congenital hypopigmentation, segmental vitiligo, any questionable diagnosis
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Illumina Human660W-Quad_v1_A 592839 1048965 - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Vitiligo
- Authorized Data Access Requests
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See articles in PMC citing this study accession
- Study Attribution
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Principal Investigator
- Richard A. Spritz, MD. University of Colorado Denver, Aurora, CO, USA.
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Institute
- Human Medical Genetics and Genomics Program.
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Funding Source
- R01AR056292. National Institutes of Health, Bethesda, MD, USA.
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Genotyping Center
- Center for Inherited Disease Research (CIDR). Johns Hopkins University, Baltimore, MD, USA.
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Funding Source for Genotyping
- HHSN268201200008I, NIH contract "High throughput genotyping for studying the genetic contributions to human disease". National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator