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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The Multiethnic Cohort (MEC) has established a large biorepository of blood and urine (N=67,000) and cryopreserved lymphocytes (N=15,000) linked to extensive, prospectively collected risk factors (e.g., diet, smoking, physical activity), biomarkers and clinical data for five racial/ethnic groups. This cohort study of over 215,000 men and women in Hawaii and California is unique in that it is population-based and includes large representations of older adults (45-75 yrs at baseline) for five US racial/ethnic groups (Japanese Americans, African Americans, European Americans, Latinos and Native Hawaiians) at varying risks of chronic diseases. Within the PAGE investigation, the MEC proposes to study: 1) diseases for which we have DNA available for large numbers of cases and controls (breast, prostate, and colorectal cancer, diabetes, and obesity); 2) important cancers that are less common (e.g., lung, pancreas, endometrial cancers, NHL) but for which we propose to pool our data with other funded groups; 3) common traits that are risk factors for these diseases (e.g., body mass index/weight, waist-to-hip ratio, height) and 4) relevant disease-associated biomarkers (e.g., fasting insulin and lipids, steroid hormones). The specific aims are: 1) To determine the population-based epidemiologic profile (allele frequency, main effect, heterogeneity by disease characteristics) of putative causal variants in the five racial/ethnic groups in the MEC; 2) for variants displaying effect heterogeneity across ethnic/racial groups, we will utilize differences in LD to identify a more complete spectrum of associated variants at these loci; 3) investigate gene x gene and gene x environment interactions to identify modifiers; 4) examine the associations of putative causal variants with already measured intermediate phenotypes (e.g., plasma insulin, lipids, steroid hormones); and 5) for variants that do not fall within known genes, start to investigate their relationships with gene expression and epigenetic patterns in small genomic studies.
This study is part of the Population Architecture using Genomics and Epidemiology (PAGE) study phs000356.
- Study Weblinks:
- Study Design:
- Case-Control
- Study Type:
- Cohort
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 27952
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Study Inclusion/Exclusion Criteria
The MEC includes approximately 12,000 individuals of ethnicities other than the five targeted groups. These individuals were not included in the biorepository and are often excluded from analyses.
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays N/A N/A Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays: MEC_HI_SNPASSAYONLY_04-14-10 8 1050508 Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays: MEC_HI_SNPASSAYONLY_09-18-11 48 1056252 Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays: MEC_HI_SNPASSAYONLY_12-7-09 74 1049710 Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays: MEC_LA_SNPASSAYONLY_12-7-09 30 1049711 Targeted Region Genotyping Applied Biosystems TaqMan OpenArrays: MEC_SNPASSAYONLY_09-15-11 292 1056251 Targeted Region Genotyping Illumina iSelect Custom Panel 7100 N/A Whole Genome Genotyping Illumina MEGA_Consortium_15063755_B2 1701459 1062317 Whole Genome Sequencing Illumina HiSeq X N/A N/A - Study History
The Multiethnic Cohort consists of 215,251 adult men and women aged 45-75 years at recruitment living in Hawaii and in California (primarily Los Angeles County) with the following ethnic distribution: African-American (16.3%), Latino (22.0%), Japanese-American (26.4%), Native Hawaiian (6.5%), White (22.9%), and other ancestry (5.8%). The sampling frame was driver's license files for Hawaii and Los Angeles, supplemented with Health Care Financing Administration (Medicare) and voter's registration file. Cohort members completed a 26-page mailed questionnaire in 1993-1996 and have been sent periodic follow-up surveys.
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Neoplasms
- Diabetes Mellitus, Type 2
- Obesity
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Glucose
- Insulin
- Authorized Data Access Requests
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See articles in PMC citing this study accession
- Study Attribution
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Principal Investigator
- Christopher Haiman, ScD. University of Southern California, Los Angeles, CA, USA.
- Loic Le Marchand, MD, PhD. University of Hawaii, Honolulu, HI, USA.
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Funding Source - Genotyping and Analysis
- U01HG007397. National Institutes of Health, Bethesda, MD, USA.
- U01HG004802. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
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Funding Source - Enrollment/Follow-up/Sample Collection (University of Hawaii)
- R37CA54281. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
- P01CA33619. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
- R01CA126895. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
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Funding Source
- U01CA136792. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
- U01CA98758. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
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Funding Source - Enrollment/Follow-up/Sample Collection (University of Southern California)
- R01CA63464. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
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Principal Investigator