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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease.
Dataset versioning
- Version 1: European-American (EA) ancestry only
- Version 2: Version 1 plus African-American (AA) ancestry
- Version 3: EA and AA samples plus updated diagnostic criteria
Consent groups and participant set
- General research use (GRU): 1767 controls (1081 EA controls, 686 AA controls)
This consent group includes all controls for the Bipolar study, which are a subset of controls for the Schizophrenia study (subset of Schizophrenia: GRU). - Bipolar and related disorders (BARD): 841 cases (691 EA cases, 150 AA cases)
This consent group includes a subset of the Bipolar cases. - Bipolar disorder only (BDO): 653 cases (388 EA cases, 265 AA cases)
This consent group includes a subset of the Bipolar cases.
- Study Weblinks:
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 3261
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Molecular Data
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Type Source Platform Number of Oligos/SNPs SNP Batch Id Comment Whole Genome Genotyping Affymetrix AFFY_6.0 934940 52074 - Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Bipolar Disorder
- Authorized Data Access Requests
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See articles in PMC citing this study accession
- Study Attribution
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Lead Principal Investigator
- John R. Kelsoe. University of California, San Diego, CA, USA.
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Co-Principal Investigator
- John Nurnberger. Indiana University, Bloomington, IN, USA.
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Institutions
- Indiana University, Bloomington, IN, USA.
- University of Chicago, IL, USA.
- Rush University Medical Center, Chicago, IL, USA.
- University of California, San Francisco, CA, USA.
- University of Iowa, Iowa City, IA, USA.
- Translational Genomics Center, Phoenix, AZ, USA.
- Johns Hopkins University, Baltimore, MD, USA.
- NIMH Intramural Program, Bethesda, MD, USA.
- Washington University, St. Louis, MO, USA.
- University of Pennsylvania, Philadelphia, PA, USA.
- Howard University, Washington, DC, USA.
- University of Michigan, Ann Arbor, MI, USA.
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Lead Principal Investigator