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Study Description

This file is the primary source for survival and follow-up used by Framingham investigators for data analysis of CVD and death.

The Survival file contains validated endpoints information and should be used in conjunction with the corresponding "Sequence of Events" file (SOE). For example, one should always use the "SOE through 2006" together with the "Survival and Follow-UP Through 2006."

In 1948, researchers recruited men and women from the town of Framingham, Massachusetts, beginning the first round of extensive physical examinations and lifestyle interviews that would later be analyzed for common patterns related to CVD development.

Initially, the Framingham Heart Study enrolled 5,209 men and women from the Framingham area who were between the ages of 28 and 62 years. Beginning in 1971, the Framingham Heart Study enrolled 5,124 men and women, who were either offspring of the original cohort or spouses of those offspring. In 2002, 4,095 third generation participants (men and women) were enrolled.

During each clinic exam cycle, the participants undergo a detailed examination including physical examination, medical history, laboratory testing, and electrocardiogram. Over the years, other tests (that may not be performed at every exam cycle) have included pulmonary function, lifestyle, physical function, cognitive function questionnaires, and various noninvasive cardiovascular tests including echocardiograms. The content of each exam cycle differs for Original, Offspring and Generation 3 cohorts and can be found in the Exam Cycle Protocol Manuals.

Authorized Access
Publicly Available Data (Public ftp)
Study Inclusion/Exclusion Criteria

Original cohort and Offspring cohort reviewed through 2006.

Study History

The Original cohort began Exam 1 in 1948 (9/1948 - 4/1953) and has continued with biennial examinations to the present.

The Offspring cohort began Exam 1 in 1971 (8/1971 - 9/1975) and has on average been examined every 3 to 4 years since enrollment. However, there was an eight year window between exam 1 and exam 2. Exam 7 was performed from 9/1998 - 10/2001.

The Generation 3 cohort Exam 1 was performed 4/2002 - 7/2005.

Examinations continue to be performed.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
Study Attribution
  • Principal Investigator
    • Philip A. Wolf, MD. Boston University School of Medicine, Boston, MA, USA and Framingham Heart Study, Framingham, MA, USA.
  • Institutions
    • The National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
    • Boston University, Boston, MA, USA.