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Collection Description

Schizophrenia is a chronic, severe, disabling brain disorder that affects approximately 1% of the population worldwide. Epidemiologic studies have clearly demonstrated that genetics play a strong role in etiology, but the inheritance is very complex. Innovative analytic approaches and creative ways of combining disparate data sets will be necessary for making breakthroughs in identifying causal pathways and ultimately new drug targets.

This dbGaP collection consists of all genetic studies of schizophrenia available in dbGaP that have been consented for general research use. The goal is to facilitate identification of datasets with related scientific content in order to expedite the application process and ascertainment of datasets of interest for increased scientific discovery.

The Open Translational Science in Schizophrenia (OPTICS) Project, was launched by Janssen Research & Development, LLC, part of the Janssen Pharmaceutical Companies of Johnson & Johnson, with a group of leading research organizations including the National Institutes of Health, Yale University School of Medicine, Rutgers University and the Harvard T.H. Chan School of Public Health, to create a new forum for collaborative analysis of Janssen's schizophrenia clinical trial data and other publicly available data about schizophrenia with the goal of creating new models for conducting research. The OPTICS project is one part of a larger effort at Janssen and other Johnson & Johnson research companies to share clinical trials data to enhance public health and advance science and medicine. Qualified investigators and physicians may apply for access to anonymized clinical trials data from Janssen, for more information please visit

Authorized Access
Studies Included in Collection

Number of subjects per molecular data type

General Research Use
Study Methylation (MDB protein, NGS)SNP Genotypes (Array)SNP Genotypes (NGS)SNP/CNV Genotypes (NGS)Whole Exome (NGS)Whole Genome (NGS)mRNA Expression (Array)
Total subjects1459103061621238012380162798
Genome-Wide Association Study of Schizophrenia

Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)

Genetics of Schizophrenia in an Ashkenazi Jewish Case-Control Cohort

Sweden-Schizophrenia Population-Based Case-Control Exome Sequencing

Whole Genome Profiling to Detect Schizophrenia Methylation Markers

Genetics of Neuropsychiatric and Neurodevelopmental Disorders

Joint Genome-Wide Gene Expression and GWAS Mapping in the MGS Dataset

Authorized Data Access Requests