Analysis Name and Accession
Analysis Name: A Genome-Wide Association Meta-Analysis Of SNP And SNP-By-Smoking Interaction (Ever/Never) For FEV1/FVC
Analysis Accession: pha003903.1

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Analysis Description
The Cohorts for Heart and Aging Research in Genomic Epimiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication among large, well-phenotyped cohort studies. CHARGE has incorporated many genomic and phenotypic data from other cohorts, depending on the phenotype. The basic design was estimation of SNP and SNP-smoking interaction effects on the outcome of FEV1/FVC as a measure of obstructive lung disease independent of lung size. Smoking in this analysis was defined as a dichotomy (ever/never). The discovery meta-analysis was conducted in 19 studies with GWAS data with European ancestry participants with FEV1/FVC and smoking data. Association analysis between genotype and genotype-smoking interaction with respect to FEV1/FVC was conducted separately within each study cohort according to a pre-specified plan. For each SNP, GWAS-specific results were combined using inverse-variance weighted meta-analysis in METAL.
Analysis Methods
Analysis Plots
The following plots were generated by dbGaP based on the data that was submitted and are not necessarily from any publications noted under Selected Publications.

Selected Publications