Analysis Name and Accession
Analysis Name: A Genome-Wide Association Meta-Analysis Of SNP And SNP-By-Smoking Interaction (Pack-Years) For FEV1
Analysis Accession: pha003902.1

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Analysis Description
The Cohorts for Heart and Aging Research in Genomic Epimiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication among large, well-phenotyped cohort studies. CHARGE has incorporated many genomic and phenotypic data from other cohorts, depending on the phenotype. The basic design was estimation of SNP and SNP-smoking interaction effects on the outcome of FEV1 as a measure of severity of obstructive lung disease. Smoking in this analysis was defined as a continuous variable (pack-years). The discovery meta-analysis was conducted in 19 studies with GWAS data with European ancestry participants with FEV1 and smoking data. Association analysis between genotype and genotype-smoking interaction with respect to FEV1 was conducted separately within each study cohort according to a pre-specified plan. For each SNP, GWAS-specific results were combined using inverse-variance weighted meta-analysis in METAL.
Analysis Methods
Each study independently implemented a predefined GWAS analysis plan. For FEV1 association with SNP genotypes and SNP-pkyrs interaction used a 2 df test of the null hypothesis (βSNP = 0 and βinteraction = 0) in a model accounting for their covariance to generate a joint test of significance. Study-specific interaction estimates (β) and standard errors were combined by fixed effects inverse variance weighted meta-analysis using METAL.
Analysis Plots
The following plots were generated by dbGaP based on the data that was submitted and are not necessarily from any publications noted under Selected Publications.

Selected Publications