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Analysis Name and Accession
Name: A Genome-Wide Association Meta-Analysis Of FEV1 In Never Smokers In Cohorts Of European Ancestry
Accession: pha003897.1

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Analysis Description
The Cohorts for Heart and Aging Research in Genomic Epimiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication among large, well-phenotyped cohort studies. CHARGE has incorporated many genomic and phenotypic data from other cohorts, depending on the phenotype. The basic design was estimation of SNP effects on FEV1 as a mesasure of severity of airflow obstruction in those participants who reported as "never smokers". The discovery meta-analysis was conducted in 5 studies with GWAS data with European ancestry participants with pulmonary function (FEV1, FVC) measures. Association analysis between genotype and FEV1 was conducted separately within each study cohort according to a pre-specified plan. For each SNP, GWAS-specific results were combined using inverse-variance weighted meta-analysis in METAL.
Analysis Methods
Each study independently implemented a predefined GWAS analysis plan. For the FEV1 trait, association with SNP genotypes used a 1 df additive model adjusted for covariates. Models were implemneted using ProbABEL (ARIC), R (CHS), linear mixed effects models with fixed effects for SNPs and random effects for individuals correlated due to family membership (FHS), and MACH2QTL (implemented in GRIMP, RS-I and RS-II). Study-specific interaction estimates (β) and standard errors were combined by fixed effects inverse variance weighted meta-analysis using METAL
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