Analysis Name and Accession
Analysis Name: A Genome-Wide Association Meta-Analysis Of MI In Response To Beta Blockers
Analysis Accession: pha003887.1

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Analysis Description
The Cohorts for Heart and Aging Research in Genomic Epimiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication among large, well-phenotyped cohort studies. CHARGE has incorporated many genomic and phenotypic data from other cohorts, depending on the phenotype. The basic design was estimation of drug-gene interactions on the outcome of myocardial infarction (MI). The discovery meta-analysis was conducted in 9 studies with GWAS data with European ancestry participants with treated hypertension. Association analysis between genotype and anti-hypertensive medication (beta blocker) with respect to MI was conducted separately within each study cohort according to a pre-specified plan. For each SNP, GWAS-specific results were combined using inverse-variance weighted meta-analysis in METAL.
Analysis Methods
Each study independently implemented a predefined GWAS analysis plan. For the qualitative outcome (MI), multiple sources of information were used to define the event and medication ascertainment. Studies evaluated drug-gene interaction using either (1) Cox proportional hazards regression models with time-varying anti-hypertensive medication exposures, entering at time of treatment and remaining at risk until first MI, death, or last follow-up; or (2) logistic regression in which all hypertensive MI cases were compared to an age- and sex-matched set of population-based hypertensive controls. All regression models included an additive SNP*drug interaction term. Study-specific interaction estimates (β) and standard errors were combined by fixed effects inverse variance weighted meta-analysis using METAL.
Analysis Plots
The following plots were generated by dbGaP based on the data that was submitted and are not necessarily from any publications noted under Selected Publications.

Selected Publications