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Analysis Name and Accession
Name: A Meta-Analysis For Fibrinogen Concentration
Accession: pha003912.1

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Analysis Description
The Cohorts for Heart and Aging Research in Genomic Epimiology (CHARGE) consortium was formed to facilitate genome-wide association study meta-analyses and replication among large, well-phenotyped cohort studies. CHARGE has incorporated many genomic and phenotypic data from other cohorts, depending on the phenotype. The basic design was estimation of SNP effects on the outcome of fibrinogen level in cohorts of European ancestry. The discovery meta-analysis was conducted in 120,246 subjects from 34 studies with GWAS data. Association analysis between genotype and log-transformed fibrinogen levell was conducted separately within each study cohort according to a pre-specified plan. For each SNP, GWAS-specific results were combined using inverse-variance weighted meta-analysis in METAL.
Analysis Methods
Each study independently implemented a predefined GWAS analysis plan. Each contributing cohort had its own GWAS platform, variant calling algorithm, call rate filter, HWE filter, MAF filter and analytic software (ProbABEL, SNPTEST, GenABEL, GWAF, PLINK, MACH2QTL, R-scripts). For the fibrinogen trait, association with SNP genotypes used a 1 df additive model adjusted for covariates (age, sex and study-specific). Study-specific estimates (β) and standard errors were combined by fixed effects inverse variance weighted meta-analysis using METAL.
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