Analysis Name and Accession
Analysis Name: Genome-Wide Association Meta-Analysis Of COPD From The International COPD Genetics Consortium (ICGC) And The UK Biobank
Analysis Accession: pha004766.1

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Analysis Description
Genome-wide association meta-analysis; included the COPDGene study, the UK Biobank, and the following ICGC cohorts: ARIC - Atherosclerosis Risk in Communities Study, Cardiovascular Health Study (African and European ancestries), ECLIPSE - Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, EOCOPD and ICGN - Boston Early-Onset COPD Study and International COPD Genetics Network, Lung Expression Quantitative Trait Loci Study, Framingham Heart Study, KARE - Korean Association Resource project, Transcontinental COPD Genetics Study, Korea, Lifelines, Lovelace, MESA - Multi-Ethnic Study of Atherosclerosis (African, European, and Hispanic ancestries), NETT/NAS - National Emphysema Treatment Trial / Normative Aging Study, GenKOLS - Bergen, Norway COPD Cohort, Transcontinental COPD Genetics Study, Poland, Rotterdam Study (1, 2 and 3), and SPIROMICS - Subpopulations and intermediate outcome measures in COPD study.
Analysis Methods
Logistic regression, with COPD as outcome, was performed in individual cohorts, checked for orientation and hg19 chr and positions. Summary statistics for each cohort were further assessed using EasyQC. Then, a fixed-effects meta-analysis was performed using METAL. Variants from the meta-analysis were only further examined if they were present in the UK Biobank as well as at least 11 ICGC studies.
Analysis Plots
The following plots were generated by dbGaP based on the data that was submitted and are not necessarily from any publications noted under Selected Publications.

Selected Publications