Genetic Epidemiology of COPD (COPDGene)

dbGaP Study Accession:  phs000179.v6.p2

List of Analyses

Analysis accession Analysis name Analysis description
pha004496.1 Genome-Wide Association Analysis Of COPD In The International COPD Genetics Consortium (All Cohorts, Primary Analysis)

Genome-wide association meta-analysis; in addition to the COPDGene study, including ARIC - Atherosclerosis Risk in Communities Study, British 1958 Birth Cohort, Cardiovascular Health Study (European ancestry), COPACETIC - COPD Pathology: Addressing Critical gaps, Early Treatment, and Innovative Conceps, ECLIPSE - Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, Lung Expression Quantitative Trait Loci Study, Framingham Heart Study, Lifelines, Lovelace Smoker's cohort, MESA - Multi-Ethnic Study of Atherosclerosis (European ancestry), NETT/NAS - National Emphysema Treatment Trial / Normative Aging Study, GenKOLS - Bergen, Norway COPD Cohort, Rotterdam Studys 1-3, SPIROMICS - Subpopulations and intermediate outcome measures in COPD study, Cardiovascular Health Study (African ancestry), KARE - Korean Association Resource project, MESA - Multi-Ethnic Study of Atherosclerosis African ancestry), MESA - Multi-Ethnic Study of Atherosclerosis (Hispanic ancestry), EOCOPD and ICGN - Boston Early-Onset COPD Study and International COPD Genetics Network, Transcontinental COPD Genetics Study, Korea, Transcontinental COPD Genetics Study, Poland.

Chronic obstructive pulmonary disease (COPD) affection status (binary) was the outcome of interest with case status defined using pre-bronchodilator spirometry values. Cases had forced expiratory volume in 1 second (FEV1) < 80% and FEV1 to forced vital capacity (FVC) ratio of < 0.7. Controls had FEV1 > 80% and FEV1/FVC > 0.7.
pha004497.1 Genome-wide association analysis of COPD in the International COPD Genetics Consortium (genome-wide European samples)

Genome-wide association meta-analysis; in addition to the COPDGene study (non-Hispanic whites), including ARIC - Atherosclerosis Risk in Communities Study, British 1958 Birth Cohort,Cardiovascular Health Study (European ancestry), COPACETIC - COPD Pathology: Addressing Critical gaps, Early Treatment, and Innovative Conceps, ECLIPSE - Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, Lung Expression Quantitative Trait Loci Study, Framingham Heart Study, Lifelines, Lovelace Smoker's cohort, MESA - Multi-Ethnic Study of Atherosclerosis (European ancestry), NETT/NAS - National Emphysema Treatment Trial / Normative Aging Study, GenKOLS - Bergen, Norway COPD Cohort, Rotterdam Studys 1-3, SPIROMICS - Subpopulations and intermediate outcome measures in COPD study.

Chronic obstructive pulmonary disease (COPD) affection status (binary) was the outcome of interest with case status defined using pre-bronchodilator spirometry values. Cases had forced expiratory volume in 1 second (FEV1) < 80% and FEV1 to forced vital capacity (FVC) ratio of < 0.7. Controls had FEV1 > 80% and FEV1/FVC > 0.7.
pha004498.1 Genome-wide association analysis of COPD in the International COPD Genetics Consortium (genome-wide samples)

Genome-wide association meta-analysis; in addition to the COPDGene study including ARIC - Atherosclerosis Risk in Communities Study, British 1958 Birth Cohort, Cardiovascular Health Study (European ancestry),COPACETIC - COPD Pathology: Addressing Critical gaps, Early Treatment, and Innovative Conceps, ECLIPSE - Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, Lung Expression Quantitative Trait Loci Study, Framingham Heart Study, Lifelines, Lovelace Smoker's cohort, MESA - Multi-Ethnic Study of Atherosclerosis (European ancestry), NETT/NAS - National Emphysema Treatment Trial / Normative Aging Study, GenKOLS - Bergen, Norway COPD Cohort, Rotterdam Studys 1-3, SPIROMICS - Subpopulations and intermediate outcome measures in COPD study, Cardiovascular Health Study (African ancestry), KARE - Korean Association Resource project, MESA - Multi-Ethnic Study of Atherosclerosis African ancestry), MESA - Multi-Ethnic Study of Atherosclerosis (Hispanic ancestry).

Chronic obstructive pulmonary disease (COPD) affection status (binary) was the outcome of interest with case status defined using pre-bronchodilator spirometry values. Cases had forced expiratory volume in 1 second (FEV1) < 80% and FEV1 to forced vital capacity (FVC) ratio of < 0.7. Controls had FEV1 > 80% and FEV1/FVC > 0.7.
pha004766.1 Genome-Wide Association Meta-Analysis Of COPD From The International COPD Genetics Consortium (ICGC) And The UK Biobank Genome-wide association meta-analysis; included the COPDGene study, the UK Biobank, and the following ICGC cohorts: ARIC - Atherosclerosis Risk in Communities Study, Cardiovascular Health Study (African and European ancestries), ECLIPSE - Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, EOCOPD and ICGN - Boston Early-Onset COPD Study and International COPD Genetics Network, Lung Expression Quantitative Trait Loci Study, Framingham Heart Study, KARE - Korean Association Resource project, Transcontinental COPD Genetics Study, Korea, Lifelines, Lovelace, MESA - Multi-Ethnic Study of Atherosclerosis (African, European, and Hispanic ancestries), NETT/NAS - National Emphysema Treatment Trial / Normative Aging Study, GenKOLS - Bergen, Norway COPD Cohort, Transcontinental COPD Genetics Study, Poland, Rotterdam Study (1, 2 and 3), and SPIROMICS - Subpopulations and intermediate outcome measures in COPD study.