Name: rs10882168
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs10882168

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr10:93169677 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: G>A / G>C / G>T
Variation Type: SNV Single Nucleotide Variation
Frequency: A=0.172186 (45576/264690, TOPMED)
A=0.155596 (31909/205076, GENOGRAPHIC)
A=0.145289 (20350/140066, GnomAD) (+ 21 more)
A=0.15244 (11916/78166, ALFA)
G=0.17039 (4815/28258, 14KJPN)
G=0.17333 (2905/16760, 8.3KJPN)
A=0.3275 (2097/6404, 1000G_30x)
A=0.3393 (1699/5008, 1000G)
A=0.1467 (657/4480, Estonian)
A=0.1326 (511/3854, ALSPAC)
A=0.1330 (493/3708, TWINSUK)
G=0.1423 (417/2930, KOREAN)
A=0.3892 (811/2084, HGDP_Stanford)
G=0.1332 (244/1832, Korea1K)
A=0.2750 (468/1702, HapMap)
A=0.132 (132/998, GoNL)
A=0.435 (272/626, Chileans)
A=0.172 (103/600, NorthernSweden)
G=0.220 (65/296, SGDP_PRJ)
A=0.065 (14/216, Qatari)
G=0.144 (31/216, Vietnamese)
A=0.15 (6/40, GENOME_DK)
G=0.34 (11/32, Siberian)
A=0.0 (0/4, Ancient Sardinia)

Clinical Significance: Not Reported in ClinVar
Gene : Consequence: None
Publications: 0 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	78166	G=0.84756	A=0.15244
European	Sub	61876	G=0.87250	A=0.12750
African	Sub	5200	G=0.9421	A=0.0579
African Others	Sub	182	G=0.967	A=0.033
African American	Sub	5018	G=0.9412	A=0.0588
Asian	Sub	238	G=0.176	A=0.824
East Asian	Sub	164	G=0.134	A=0.866
Other Asian	Sub	74	G=0.27	A=0.73
Latin American 1	Sub	400	G=0.858	A=0.142
Latin American 2	Sub	3370	G=0.5736	A=0.4264
South Asian	Sub	4968	G=0.6930	A=0.3070
Other	Sub	2114	G=0.7583	A=0.2417

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	G=0.827814	A=0.172186
Genographic Project	Global	Study-wide	205076	G=0.844404	A=0.155596
gnomAD - Genomes	Global	Study-wide	140066	G=0.854711	A=0.145289
gnomAD - Genomes	European	Sub	75854	G=0.86237	A=0.13763
gnomAD - Genomes	African	Sub	41992	G=0.93896	A=0.06104
gnomAD - Genomes	American	Sub	13626	G=0.71466	A=0.28534
gnomAD - Genomes	Ashkenazi Jewish	Sub	3318	G=0.9114	A=0.0886
gnomAD - Genomes	East Asian	Sub	3126	G=0.1027	A=0.8973
gnomAD - Genomes	Other	Sub	2150	G=0.8326	A=0.1674
Allele Frequency Aggregator	Total	Global	78166	G=0.84756	A=0.15244
Allele Frequency Aggregator	European	Sub	61876	G=0.87250	A=0.12750
Allele Frequency Aggregator	African	Sub	5200	G=0.9421	A=0.0579
Allele Frequency Aggregator	South Asian	Sub	4968	G=0.6930	A=0.3070
Allele Frequency Aggregator	Latin American 2	Sub	3370	G=0.5736	A=0.4264
Allele Frequency Aggregator	Other	Sub	2114	G=0.7583	A=0.2417
Allele Frequency Aggregator	Latin American 1	Sub	400	G=0.858	A=0.142
Allele Frequency Aggregator	Asian	Sub	238	G=0.176	A=0.824
14KJPN	JAPANESE	Study-wide	28258	G=0.17039	A=0.82961
8.3KJPN	JAPANESE	Study-wide	16760	G=0.17333	A=0.82667
1000Genomes_30x	Global	Study-wide	6404	G=0.6725	A=0.3275
1000Genomes_30x	African	Sub	1786	G=0.9681	A=0.0319
1000Genomes_30x	Europe	Sub	1266	G=0.8744	A=0.1256
1000Genomes_30x	South Asian	Sub	1202	G=0.6082	A=0.3918
1000Genomes_30x	East Asian	Sub	1170	G=0.1256	A=0.8744
1000Genomes_30x	American	Sub	980	G=0.605	A=0.395
1000Genomes	Global	Study-wide	5008	G=0.6607	A=0.3393
1000Genomes	African	Sub	1322	G=0.9697	A=0.0303
1000Genomes	East Asian	Sub	1008	G=0.1329	A=0.8671
1000Genomes	Europe	Sub	1006	G=0.8728	A=0.1272
1000Genomes	South Asian	Sub	978	G=0.611	A=0.389
1000Genomes	American	Sub	694	G=0.601	A=0.399
Genetic variation in the Estonian population	Estonian	Study-wide	4480	G=0.8533	A=0.1467
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.8674	A=0.1326
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.8670	A=0.1330
KOREAN population from KRGDB	KOREAN	Study-wide	2930	G=0.1423	A=0.8577, C=0.0000, T=0.0000
HGDP-CEPH-db Supplement 1	Global	Study-wide	2084	G=0.6108	A=0.3892
HGDP-CEPH-db Supplement 1	Est_Asia	Sub	470	G=0.126	A=0.874
HGDP-CEPH-db Supplement 1	Central_South_Asia	Sub	414	G=0.700	A=0.300
HGDP-CEPH-db Supplement 1	Middle_Est	Sub	350	G=0.954	A=0.046
HGDP-CEPH-db Supplement 1	Europe	Sub	320	G=0.847	A=0.153
HGDP-CEPH-db Supplement 1	Africa	Sub	242	G=0.988	A=0.012
HGDP-CEPH-db Supplement 1	America	Sub	216	G=0.106	A=0.894
HGDP-CEPH-db Supplement 1	Oceania	Sub	72	G=0.79	A=0.21
Korean Genome Project	KOREAN	Study-wide	1832	G=0.1332	A=0.8668
HapMap	Global	Study-wide	1702	G=0.7250	A=0.2750
HapMap	African	Sub	692	G=0.980	A=0.020
HapMap	American	Sub	588	G=0.614	A=0.386
HapMap	Asian	Sub	254	G=0.181	A=0.819
HapMap	Europe	Sub	168	G=0.887	A=0.113
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	G=0.868	A=0.132
Chileans	Chilean	Study-wide	626	G=0.565	A=0.435
Northern Sweden	ACPOP	Study-wide	600	G=0.828	A=0.172
SGDP_PRJ	Global	Study-wide	296	G=0.220	A=0.780
Qatari	Global	Study-wide	216	G=0.935	A=0.065
A Vietnamese Genetic Variation Database	Global	Study-wide	216	G=0.144	A=0.856
The Danish reference pan genome	Danish	Study-wide	40	G=0.85	A=0.15
Siberian	Global	Study-wide	32	G=0.34	A=0.66
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	4	G=1.0	A=0.0

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 10	NC_000010.11:g.93169677G>A
GRCh38.p14 chr 10	NC_000010.11:g.93169677G>C
GRCh38.p14 chr 10	NC_000010.11:g.93169677G>T
GRCh37.p13 chr 10	NC_000010.10:g.94929434G>A
GRCh37.p13 chr 10	NC_000010.10:g.94929434G>C
GRCh37.p13 chr 10	NC_000010.10:g.94929434G>T

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	G=	A	C	T
GRCh38.p14 chr 10	NC_000010.11:g.93169677=	NC_000010.11:g.93169677G>A	NC_000010.11:g.93169677G>C	NC_000010.11:g.93169677G>T
GRCh37.p13 chr 10	NC_000010.10:g.94929434=	NC_000010.10:g.94929434G>A	NC_000010.10:g.94929434G>C	NC_000010.10:g.94929434G>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

84 SubSNP, 24 Frequency submissions

No	Submitter	Submission ID	Date (Build)
1	SC_SNP	ss15582341	Feb 27, 2004 (120)
2	SC_SNP	ss18415422	Feb 27, 2004 (120)
3	SC_SNP	ss18622255	Feb 27, 2004 (120)
4	AFFY	ss66395784	Nov 30, 2006 (127)
5	ILLUMINA	ss66634500	Nov 30, 2006 (127)
6	ILLUMINA	ss66907459	Nov 30, 2006 (127)
7	ILLUMINA	ss67034573	Nov 30, 2006 (127)
8	ILLUMINA	ss70383446	May 17, 2007 (127)
9	ILLUMINA	ss70504990	May 26, 2008 (130)
10	ILLUMINA	ss71031442	May 17, 2007 (127)
11	ILLUMINA	ss75522375	Dec 07, 2007 (129)
12	AFFY	ss76140602	Dec 07, 2007 (129)
13	KRIBB_YJKIM	ss85022818	Dec 16, 2007 (130)
14	BGI	ss106694960	Feb 06, 2009 (130)
15	1000GENOMES	ss109659110	Jan 24, 2009 (130)
16	ILLUMINA	ss121410092	Dec 01, 2009 (131)
17	ILLUMINA	ss152860826	Dec 01, 2009 (131)
18	GMI	ss155391559	Dec 01, 2009 (131)
19	ILLUMINA	ss159150103	Dec 01, 2009 (131)
20	ILLUMINA	ss169692491	Jul 04, 2010 (132)
21	ILLUMINA	ss170697159	Jul 04, 2010 (132)
22	AFFY	ss172620064	Jul 04, 2010 (132)
23	BCM-HGSC-SUB	ss207217582	Jul 04, 2010 (132)
24	1000GENOMES	ss211023473	Jul 14, 2010 (132)
25	1000GENOMES	ss224878184	Jul 14, 2010 (132)
26	1000GENOMES	ss235288171	Jul 15, 2010 (132)
27	1000GENOMES	ss241972436	Jul 15, 2010 (132)
28	GMI	ss280728148	May 04, 2012 (137)
29	ILLUMINA	ss536648023	Sep 08, 2015 (146)
30	SSMP	ss657171533	Apr 25, 2013 (138)
31	ILLUMINA	ss825352936	Apr 01, 2015 (144)
32	ILLUMINA	ss832662722	Jul 13, 2019 (153)
33	EVA-GONL	ss987792064	Aug 21, 2014 (142)
34	JMKIDD_LAB	ss1077206735	Aug 21, 2014 (142)
35	1000GENOMES	ss1338578893	Aug 21, 2014 (142)
36	EVA_GENOME_DK	ss1575290496	Apr 01, 2015 (144)
37	EVA_DECODE	ss1597465364	Apr 01, 2015 (144)
38	EVA_UK10K_ALSPAC	ss1625171622	Apr 01, 2015 (144)
39	EVA_UK10K_TWINSUK	ss1668165655	Apr 01, 2015 (144)
40	EVA_SVP	ss1713201744	Apr 01, 2015 (144)
41	WEILL_CORNELL_DGM	ss1931158453	Feb 12, 2016 (147)
42	GENOMED	ss1967197406	Jul 19, 2016 (147)
43	JJLAB	ss2026307851	Sep 14, 2016 (149)
44	USC_VALOUEV	ss2154583958	Nov 08, 2017 (151)
45	HUMAN_LONGEVITY	ss2177057631	Dec 20, 2016 (150)
46	SYSTEMSBIOZJU	ss2627622559	Nov 08, 2017 (151)
47	GRF	ss2698836315	Nov 08, 2017 (151)
48	GNOMAD	ss2892004541	Nov 08, 2017 (151)
49	SWEGEN	ss3006947376	Nov 08, 2017 (151)
50	BIOINF_KMB_FNS_UNIBA	ss3026943738	Nov 08, 2017 (151)
51	CSHL	ss3349256270	Nov 08, 2017 (151)
52	ILLUMINA	ss3626507201	Oct 12, 2018 (152)
53	ILLUMINA	ss3637866531	Oct 12, 2018 (152)
54	ILLUMINA	ss3638949106	Oct 12, 2018 (152)
55	ILLUMINA	ss3639474577	Oct 12, 2018 (152)
56	ILLUMINA	ss3642868656	Oct 12, 2018 (152)
57	EGCUT_WGS	ss3674359557	Jul 13, 2019 (153)
58	EVA_DECODE	ss3690439216	Jul 13, 2019 (153)
59	ACPOP	ss3737575452	Jul 13, 2019 (153)
60	EVA	ss3748455017	Jul 13, 2019 (153)
61	KHV_HUMAN_GENOMES	ss3813821004	Jul 13, 2019 (153)
62	EVA	ss3832270576	Apr 26, 2020 (154)
63	EVA	ss3839676430	Apr 26, 2020 (154)
64	EVA	ss3845150030	Apr 26, 2020 (154)
65	HGDP	ss3847395670	Apr 26, 2020 (154)
66	SGDP_PRJ	ss3874805150	Apr 26, 2020 (154)
67	KRGDB	ss3922930507	Apr 26, 2020 (154)
68	KOGIC	ss3968436831	Apr 26, 2020 (154)
69	EVA	ss3985492581	Apr 26, 2021 (155)
70	EVA	ss4017500886	Apr 26, 2021 (155)
71	TOPMED	ss4862246284	Apr 26, 2021 (155)
72	TOMMO_GENOMICS	ss5198920241	Apr 26, 2021 (155)
73	1000G_HIGH_COVERAGE	ss5285049602	Oct 16, 2022 (156)
74	GENOGRAPHIC	ss5314541307	Oct 16, 2022 (156)
75	HUGCELL_USP	ss5480513125	Oct 16, 2022 (156)
76	EVA	ss5510125177	Oct 16, 2022 (156)
77	1000G_HIGH_COVERAGE	ss5579506926	Oct 16, 2022 (156)
78	SANFORD_IMAGENETICS	ss5649864089	Oct 16, 2022 (156)
79	TOMMO_GENOMICS	ss5745122836	Oct 16, 2022 (156)
80	YY_MCH	ss5811783097	Oct 16, 2022 (156)
81	EVA	ss5824792680	Oct 16, 2022 (156)
82	EVA	ss5849692354	Oct 16, 2022 (156)
83	EVA	ss5880040862	Oct 16, 2022 (156)
84	EVA	ss5941149182	Oct 16, 2022 (156)
85	1000Genomes	NC_000010.10 - 94929434	Oct 12, 2018 (152)
86	1000Genomes_30x	NC_000010.11 - 93169677	Oct 16, 2022 (156)
87	The Avon Longitudinal Study of Parents and Children	NC_000010.10 - 94929434	Oct 12, 2018 (152)
88	Chileans	NC_000010.10 - 94929434	Apr 26, 2020 (154)
89	Genetic variation in the Estonian population	NC_000010.10 - 94929434	Oct 12, 2018 (152)
90	Genographic Project	NC_000010.11 - 93169677	Oct 16, 2022 (156)
91	The Danish reference pan genome	NC_000010.10 - 94929434	Apr 26, 2020 (154)
92	gnomAD - Genomes	NC_000010.11 - 93169677	Apr 26, 2021 (155)
93	Genome of the Netherlands Release 5	NC_000010.10 - 94929434	Apr 26, 2020 (154)
94	HGDP-CEPH-db Supplement 1	NC_000010.9 - 94919424	Apr 26, 2020 (154)
95	HapMap	NC_000010.11 - 93169677	Apr 26, 2020 (154)
96	KOREAN population from KRGDB	NC_000010.10 - 94929434	Apr 26, 2020 (154)
97	Korean Genome Project	NC_000010.11 - 93169677	Apr 26, 2020 (154)
98	Northern Sweden	NC_000010.10 - 94929434	Jul 13, 2019 (153)
99	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000010.10 - 94929434	Apr 26, 2021 (155)
100	Qatari	NC_000010.10 - 94929434	Apr 26, 2020 (154)
101	SGDP_PRJ	NC_000010.10 - 94929434	Apr 26, 2020 (154)
102	Siberian	NC_000010.10 - 94929434	Apr 26, 2020 (154)
103	8.3KJPN	NC_000010.10 - 94929434	Apr 26, 2021 (155)
104	14KJPN	NC_000010.11 - 93169677	Oct 16, 2022 (156)
105	TopMed	NC_000010.11 - 93169677	Apr 26, 2021 (155)
106	UK 10K study - Twins	NC_000010.10 - 94929434	Oct 12, 2018 (152)
107	A Vietnamese Genetic Variation Database	NC_000010.10 - 94929434	Jul 13, 2019 (153)
108	ALFA	NC_000010.11 - 93169677	Apr 26, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs61482839	May 26, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss3638949106, ss3639474577	NC_000010.8:94919423:G:A	NC_000010.11:93169676:G:A	(self)
73562, ss109659110, ss207217582, ss211023473, ss280728148, ss825352936, ss1597465364, ss1713201744, ss3642868656, ss3847395670	NC_000010.9:94919423:G:A	NC_000010.11:93169676:G:A	(self)
51008682, 28318617, 58085, 20097805, 2278265, 12627189, 30107901, 10860317, 718508, 13200383, 26822130, 7100312, 56889548, 28318617, 6288702, ss224878184, ss235288171, ss241972436, ss536648023, ss657171533, ss832662722, ss987792064, ss1077206735, ss1338578893, ss1575290496, ss1625171622, ss1668165655, ss1931158453, ss1967197406, ss2026307851, ss2154583958, ss2627622559, ss2698836315, ss2892004541, ss3006947376, ss3349256270, ss3626507201, ss3637866531, ss3674359557, ss3737575452, ss3748455017, ss3832270576, ss3839676430, ss3874805150, ss3922930507, ss3985492581, ss4017500886, ss5198920241, ss5510125177, ss5649864089, ss5824792680, ss5941149182	NC_000010.10:94929433:G:A	NC_000010.11:93169676:G:A	(self)
67032861, 99891, 360417675, 465869, 24814832, 78959940, 77791939, 10414159265, ss2177057631, ss3026943738, ss3690439216, ss3813821004, ss3845150030, ss3968436831, ss4862246284, ss5285049602, ss5314541307, ss5480513125, ss5579506926, ss5745122836, ss5811783097, ss5849692354, ss5880040862	NC_000010.11:93169676:G:A	NC_000010.11:93169676:G:A	(self)
ss15582341, ss18415422, ss18622255	NT_030059.11:13677959:G:A	NC_000010.11:93169676:G:A	(self)
ss66395784, ss66634500, ss66907459, ss67034573, ss70383446, ss70504990, ss71031442, ss75522375, ss76140602, ss85022818, ss106694960, ss121410092, ss152860826, ss155391559, ss159150103, ss169692491, ss170697159, ss172620064	NT_030059.13:45733897:G:A	NC_000010.11:93169676:G:A	(self)
30107901, ss3922930507	NC_000010.10:94929433:G:C	NC_000010.11:93169676:G:C	(self)
30107901, ss3922930507	NC_000010.10:94929433:G:T	NC_000010.11:93169676:G:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

No publications for rs10882168

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
Top▲ Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs10882168