Name: rs10811661
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs10811661

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr9:22134095 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: T>A / T>C
Variation Type: SNV Single Nucleotide Variation
Frequency: C=0.145903 (38619/264690, TOPMED)
C=0.169932 (31916/187816, ALFA)
C=0.141222 (19796/140176, GnomAD) (+ 22 more)
C=0.15170 (11938/78694, PAGE_STUDY)
C=0.42243 (11937/28258, 14KJPN)
C=0.42691 (7155/16760, 8.3KJPN)
C=0.1710 (1095/6404, 1000G_30x)
C=0.1763 (883/5008, 1000G)
C=0.1353 (606/4480, Estonian)
C=0.1879 (724/3854, ALSPAC)
C=0.1775 (658/3708, TWINSUK)
C=0.4290 (1257/2930, KOREAN)
C=0.1849 (348/1882, HapMap)
C=0.4187 (767/1832, Korea1K)
C=0.1549 (176/1136, Daghestan)
C=0.185 (185/998, GoNL)
C=0.477 (377/790, PRJEB37584)
C=0.136 (85/626, Chileans)
C=0.255 (153/600, NorthernSweden)
T=0.428 (95/222, SGDP_PRJ)
C=0.139 (30/216, Qatari)
C=0.416 (89/214, Vietnamese)
C=0.26 (24/92, Ancient Sardinia)
C=0.15 (6/40, GENOME_DK)
T=0.46 (13/28, Siberian)

Clinical Significance: Not Reported in ClinVar
Gene : Consequence: None
Publications: 223 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	192946	T=0.830424	C=0.169576
European	Sub	159666	T=0.828241	C=0.171759
African	Sub	10256	T=0.93467	C=0.06533
African Others	Sub	384	T=0.951	C=0.049
African American	Sub	9872	T=0.9341	C=0.0659
Asian	Sub	3712	T=0.5741	C=0.4259
East Asian	Sub	3016	T=0.5653	C=0.4347
Other Asian	Sub	696	T=0.612	C=0.388
Latin American 1	Sub	1008	T=0.8532	C=0.1468
Latin American 2	Sub	7376	T=0.8712	C=0.1288
South Asian	Sub	358	T=0.858	C=0.142
Other	Sub	10570	T=0.82072	C=0.17928

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	T=0.854097	C=0.145903
Allele Frequency Aggregator	Total	Global	187816	T=0.830068	C=0.169932
Allele Frequency Aggregator	European	Sub	156496	T=0.828552	C=0.171448
Allele Frequency Aggregator	Other	Sub	9752	T=0.8199	C=0.1801
Allele Frequency Aggregator	African	Sub	9114	T=0.9343	C=0.0657
Allele Frequency Aggregator	Latin American 2	Sub	7376	T=0.8712	C=0.1288
Allele Frequency Aggregator	Asian	Sub	3712	T=0.5741	C=0.4259
Allele Frequency Aggregator	Latin American 1	Sub	1008	T=0.8532	C=0.1468
Allele Frequency Aggregator	South Asian	Sub	358	T=0.858	C=0.142
gnomAD - Genomes	Global	Study-wide	140176	T=0.858778	C=0.141222
gnomAD - Genomes	European	Sub	75896	T=0.83321	C=0.16679
gnomAD - Genomes	African	Sub	42034	T=0.93248	C=0.06752
gnomAD - Genomes	American	Sub	13650	T=0.83993	C=0.16007
gnomAD - Genomes	Ashkenazi Jewish	Sub	3324	T=0.8384	C=0.1616
gnomAD - Genomes	East Asian	Sub	3122	T=0.5990	C=0.4010
gnomAD - Genomes	Other	Sub	2150	T=0.8488	C=0.1512
The PAGE Study	Global	Study-wide	78694	T=0.84830	C=0.15170
The PAGE Study	AfricanAmerican	Sub	32514	T=0.93006	C=0.06994
The PAGE Study	Mexican	Sub	10810	T=0.88113	C=0.11887
The PAGE Study	Asian	Sub	8312	T=0.5740	C=0.4260
The PAGE Study	PuertoRican	Sub	7918	T=0.8534	C=0.1466
The PAGE Study	NativeHawaiian	Sub	4534	T=0.6409	C=0.3591
The PAGE Study	Cuban	Sub	4230	T=0.8343	C=0.1657
The PAGE Study	Dominican	Sub	3828	T=0.8764	C=0.1236
The PAGE Study	CentralAmerican	Sub	2450	T=0.8751	C=0.1249
The PAGE Study	SouthAmerican	Sub	1982	T=0.8653	C=0.1347
The PAGE Study	NativeAmerican	Sub	1260	T=0.8532	C=0.1468
The PAGE Study	SouthAsian	Sub	856	T=0.863	C=0.137
14KJPN	JAPANESE	Study-wide	28258	T=0.57757	C=0.42243
8.3KJPN	JAPANESE	Study-wide	16760	T=0.57309	C=0.42691
1000Genomes_30x	Global	Study-wide	6404	T=0.8290	C=0.1710
1000Genomes_30x	African	Sub	1786	T=0.9563	C=0.0437
1000Genomes_30x	Europe	Sub	1266	T=0.8278	C=0.1722
1000Genomes_30x	South Asian	Sub	1202	T=0.8669	C=0.1331
1000Genomes_30x	East Asian	Sub	1170	T=0.5590	C=0.4410
1000Genomes_30x	American	Sub	980	T=0.874	C=0.126
1000Genomes	Global	Study-wide	5008	T=0.8237	C=0.1763
1000Genomes	African	Sub	1322	T=0.9546	C=0.0454
1000Genomes	East Asian	Sub	1008	T=0.5645	C=0.4355
1000Genomes	Europe	Sub	1006	T=0.8320	C=0.1680
1000Genomes	South Asian	Sub	978	T=0.868	C=0.132
1000Genomes	American	Sub	694	T=0.876	C=0.124
Genetic variation in the Estonian population	Estonian	Study-wide	4480	T=0.8647	C=0.1353
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.8121	C=0.1879
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.8225	C=0.1775
KOREAN population from KRGDB	KOREAN	Study-wide	2930	T=0.5710	A=0.0000, C=0.4290
HapMap	Global	Study-wide	1882	T=0.8151	C=0.1849
HapMap	American	Sub	770	T=0.796	C=0.204
HapMap	African	Sub	684	T=0.937	C=0.063
HapMap	Asian	Sub	252	T=0.544	C=0.456
HapMap	Europe	Sub	176	T=0.812	C=0.188
Korean Genome Project	KOREAN	Study-wide	1832	T=0.5813	C=0.4187
Genome-wide autozygosity in Daghestan	Global	Study-wide	1136	T=0.8451	C=0.1549
Genome-wide autozygosity in Daghestan	Daghestan	Sub	628	T=0.877	C=0.123
Genome-wide autozygosity in Daghestan	Near_East	Sub	144	T=0.854	C=0.146
Genome-wide autozygosity in Daghestan	Central Asia	Sub	122	T=0.746	C=0.254
Genome-wide autozygosity in Daghestan	Europe	Sub	108	T=0.833	C=0.167
Genome-wide autozygosity in Daghestan	South Asian	Sub	98	T=0.82	C=0.18
Genome-wide autozygosity in Daghestan	Caucasus	Sub	36	T=0.69	C=0.31
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	T=0.815	C=0.185
CNV burdens in cranial meningiomas	Global	Study-wide	790	T=0.523	C=0.477
CNV burdens in cranial meningiomas	CRM	Sub	790	T=0.523	C=0.477
Chileans	Chilean	Study-wide	626	T=0.864	C=0.136
Northern Sweden	ACPOP	Study-wide	600	T=0.745	C=0.255
SGDP_PRJ	Global	Study-wide	222	T=0.428	C=0.572
Qatari	Global	Study-wide	216	T=0.861	C=0.139
A Vietnamese Genetic Variation Database	Global	Study-wide	214	T=0.584	C=0.416
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	92	T=0.74	C=0.26
The Danish reference pan genome	Danish	Study-wide	40	T=0.85	C=0.15
Siberian	Global	Study-wide	28	T=0.46	C=0.54

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 9	NC_000009.12:g.22134095T>A
GRCh38.p14 chr 9	NC_000009.12:g.22134095T>C
GRCh37.p13 chr 9	NC_000009.11:g.22134094T>A
GRCh37.p13 chr 9	NC_000009.11:g.22134094T>C

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	T=	A	C
GRCh38.p14 chr 9	NC_000009.12:g.22134095=	NC_000009.12:g.22134095T>A	NC_000009.12:g.22134095T>C
GRCh37.p13 chr 9	NC_000009.11:g.22134094=	NC_000009.11:g.22134094T>A	NC_000009.11:g.22134094T>C

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

98 SubSNP, 25 Frequency submissions

No	Submitter	Submission ID	Date (Build)
1	SC_SNP	ss15954995	Feb 27, 2004 (120)
2	SC_SNP	ss18606193	Feb 27, 2004 (120)
3	SC_SNP	ss19057714	Feb 27, 2004 (120)
4	AFFY	ss66064046	Nov 29, 2006 (127)
5	AFFY	ss75986202	Dec 08, 2007 (130)
6	KRIBB_YJKIM	ss82771277	Dec 15, 2007 (130)
7	BGI	ss104605567	Dec 01, 2009 (131)
8	RSG_JCVI	ss107934366	Feb 04, 2009 (130)
9	WTCCC	ss120256078	Dec 01, 2009 (131)
10	ILLUMINA	ss159924101	Dec 01, 2009 (131)
11	AFFY	ss170043166	Jun 24, 2010 (142)
12	PAGE_STUDY	ss181341851	Jul 04, 2010 (132)
13	PAGE_STUDY	ss181834428	Jul 04, 2010 (132)
14	PAGE_STUDY	ss181835895	Jul 04, 2010 (132)
15	1000GENOMES	ss224175948	Jul 14, 2010 (132)
16	WTCCC	ss230393063	Jul 04, 2010 (132)
17	1000GENOMES	ss234764887	Jul 15, 2010 (132)
18	1000GENOMES	ss241550389	Jul 15, 2010 (132)
19	ILLUMINA	ss244270289	Jul 04, 2010 (132)
20	GMI	ss280150195	May 04, 2012 (137)
21	GMI	ss285987888	Apr 25, 2013 (138)
22	ILLUMINA	ss410889041	Sep 17, 2011 (135)
23	BROAD_NHGRI_T2D	ss411632917	Jul 19, 2016 (147)
24	ILLUMINA	ss479762335	Sep 08, 2015 (146)
25	EXOME_CHIP	ss491421335	May 04, 2012 (137)
26	TISHKOFF	ss561303806	Apr 25, 2013 (138)
27	SSMP	ss655735666	Apr 25, 2013 (138)
28	EVA-GONL	ss986414542	Aug 21, 2014 (142)
29	JMKIDD_LAB	ss1076193597	Aug 21, 2014 (142)
30	1000GENOMES	ss1333300101	Aug 21, 2014 (142)
31	HAMMER_LAB	ss1397551633	Sep 08, 2015 (146)
32	DDI	ss1431782562	Apr 01, 2015 (144)
33	EVA_GENOME_DK	ss1583029205	Apr 01, 2015 (144)
34	EVA_DECODE	ss1596048741	Apr 01, 2015 (144)
35	EVA_UK10K_ALSPAC	ss1622458202	Apr 01, 2015 (144)
36	EVA_UK10K_TWINSUK	ss1665452235	Apr 01, 2015 (144)
37	EVA_SVP	ss1713099093	Apr 01, 2015 (144)
38	WEILL_CORNELL_DGM	ss1929697918	Feb 12, 2016 (147)
39	ILLUMINA	ss1946255407	Feb 12, 2016 (147)
40	ILLUMINA	ss1959173175	Feb 12, 2016 (147)
41	GENOMED	ss1971178691	Jul 19, 2016 (147)
42	JJLAB	ss2025560956	Sep 14, 2016 (149)
43	ILLUMINA	ss2094835220	Dec 20, 2016 (150)
44	ILLUMINA	ss2095220497	Dec 20, 2016 (150)
45	USC_VALOUEV	ss2153787198	Dec 20, 2016 (150)
46	HUMAN_LONGEVITY	ss2310213898	Dec 20, 2016 (150)
47	SYSTEMSBIOZJU	ss2627255104	Nov 08, 2017 (151)
48	ILLUMINA	ss2634850098	Nov 08, 2017 (151)
49	ILLUMINA	ss2634850099	Nov 08, 2017 (151)
50	ILLUMINA	ss2635194098	Nov 08, 2017 (151)
51	GRF	ss2709591773	Nov 08, 2017 (151)
52	ILLUMINA	ss2711159951	Nov 08, 2017 (151)
53	GNOMAD	ss2876542304	Nov 08, 2017 (151)
54	AFFY	ss2985458499	Nov 08, 2017 (151)
55	AFFY	ss2986104589	Nov 08, 2017 (151)
56	SWEGEN	ss3004538153	Nov 08, 2017 (151)
57	ILLUMINA	ss3022917204	Nov 08, 2017 (151)
58	BIOINF_KMB_FNS_UNIBA	ss3026570211	Nov 08, 2017 (151)
59	CSHL	ss3348570207	Nov 08, 2017 (151)
60	ILLUMINA	ss3625980850	Oct 12, 2018 (152)
61	ILLUMINA	ss3636952435	Oct 12, 2018 (152)
62	ILLUMINA	ss3644988719	Oct 12, 2018 (152)
63	ILLUMINA	ss3653468368	Oct 12, 2018 (152)
64	ILLUMINA	ss3654222526	Oct 12, 2018 (152)
65	EGCUT_WGS	ss3672284650	Jul 13, 2019 (153)
66	EVA_DECODE	ss3723661857	Jul 13, 2019 (153)
67	ILLUMINA	ss3726601652	Jul 13, 2019 (153)
68	ACPOP	ss3736393870	Jul 13, 2019 (153)
69	ILLUMINA	ss3744317644	Jul 13, 2019 (153)
70	ILLUMINA	ss3744587248	Jul 13, 2019 (153)
71	EVA	ss3769037098	Jul 13, 2019 (153)
72	PAGE_CC	ss3771492532	Jul 13, 2019 (153)
73	JVAR_NIG-HUMG	ss3798740378	Jul 13, 2019 (153)
74	KHV_HUMAN_GENOMES	ss3812194174	Jul 13, 2019 (153)
75	EVA	ss3831586943	Apr 26, 2020 (154)
76	SGDP_PRJ	ss3871729440	Apr 26, 2020 (154)
77	KRGDB	ss3919387880	Apr 26, 2020 (154)
78	KOGIC	ss3965479750	Apr 26, 2020 (154)
79	EVA	ss3984617755	Apr 26, 2021 (155)
80	EVA	ss3985412212	Apr 26, 2021 (155)
81	TOPMED	ss4816112229	Apr 26, 2021 (155)
82	TOMMO_GENOMICS	ss5192521333	Apr 26, 2021 (155)
83	EVA	ss5237456872	Apr 26, 2021 (155)
84	1000G_HIGH_COVERAGE	ss5280135098	Oct 16, 2022 (156)
85	EVA	ss5386658220	Oct 16, 2022 (156)
86	HUGCELL_USP	ss5476377723	Oct 16, 2022 (156)
87	1000G_HIGH_COVERAGE	ss5572084656	Oct 16, 2022 (156)
88	SANFORD_IMAGENETICS	ss5624716126	Oct 16, 2022 (156)
89	SANFORD_IMAGENETICS	ss5647103152	Oct 16, 2022 (156)
90	TOMMO_GENOMICS	ss5735693435	Oct 16, 2022 (156)
91	YY_MCH	ss5810428235	Oct 16, 2022 (156)
92	EVA	ss5828981299	Oct 16, 2022 (156)
93	EVA	ss5847353897	Oct 16, 2022 (156)
94	EVA	ss5848201854	Oct 16, 2022 (156)
95	EVA	ss5856712264	Oct 16, 2022 (156)
96	EVA	ss5915918080	Oct 16, 2022 (156)
97	EVA	ss5976380988	Oct 16, 2022 (156)
98	EVA	ss5979889129	Oct 16, 2022 (156)
99	1000Genomes	NC_000009.11 - 22134094	Oct 12, 2018 (152)
100	1000Genomes_30x	NC_000009.12 - 22134095	Oct 16, 2022 (156)
101	The Avon Longitudinal Study of Parents and Children	NC_000009.11 - 22134094	Oct 12, 2018 (152)
102	Chileans	NC_000009.11 - 22134094	Apr 26, 2020 (154)
103	Genome-wide autozygosity in Daghestan	NC_000009.10 - 22124094	Apr 26, 2020 (154)
104	Genetic variation in the Estonian population	NC_000009.11 - 22134094	Oct 12, 2018 (152)
105	The Danish reference pan genome	NC_000009.11 - 22134094	Apr 26, 2020 (154)
106	gnomAD - Genomes	NC_000009.12 - 22134095	Apr 26, 2021 (155)
107	Genome of the Netherlands Release 5	NC_000009.11 - 22134094	Apr 26, 2020 (154)
108	HapMap	NC_000009.12 - 22134095	Apr 26, 2020 (154)
109	KOREAN population from KRGDB	NC_000009.11 - 22134094	Apr 26, 2020 (154)
110	Korean Genome Project	NC_000009.12 - 22134095	Apr 26, 2020 (154)
111	Northern Sweden	NC_000009.11 - 22134094	Jul 13, 2019 (153)
112	The PAGE Study	NC_000009.12 - 22134095	Jul 13, 2019 (153)
113	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000009.11 - 22134094	Apr 26, 2021 (155)
114	CNV burdens in cranial meningiomas	NC_000009.11 - 22134094	Apr 26, 2021 (155)
115	Qatari	NC_000009.11 - 22134094	Apr 26, 2020 (154)
116	SGDP_PRJ	NC_000009.11 - 22134094	Apr 26, 2020 (154)
117	Siberian	NC_000009.11 - 22134094	Apr 26, 2020 (154)
118	8.3KJPN	NC_000009.11 - 22134094	Apr 26, 2021 (155)
119	14KJPN	NC_000009.12 - 22134095	Oct 16, 2022 (156)
120	TopMed	NC_000009.12 - 22134095	Apr 26, 2021 (155)
121	UK 10K study - Twins	NC_000009.11 - 22134094	Oct 12, 2018 (152)
122	A Vietnamese Genetic Variation Database	NC_000009.11 - 22134094	Jul 13, 2019 (153)
123	ALFA	NC_000009.12 - 22134095	Apr 26, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs56432185	May 24, 2008 (130)
rs60839437	Feb 26, 2009 (130)
rs111169537	Aug 21, 2014 (142)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
26565274, ss3919387880	NC_000009.11:22134093:T:A	NC_000009.12:22134094:T:A	(self)
525172, ss66064046, ss75986202, ss170043166, ss280150195, ss285987888, ss1397551633, ss1596048741, ss1713099093, ss2635194098	NC_000009.10:22124093:T:C	NC_000009.12:22134094:T:C	(self)
45539431, 25332118, 456289, 18022898, 9194142, 11299891, 26565274, 9678735, 638139, 167200, 11739848, 23746420, 6303552, 50490640, 25332118, 5627092, ss224175948, ss234764887, ss241550389, ss479762335, ss491421335, ss561303806, ss655735666, ss986414542, ss1076193597, ss1333300101, ss1431782562, ss1583029205, ss1622458202, ss1665452235, ss1929697918, ss1946255407, ss1959173175, ss1971178691, ss2025560956, ss2094835220, ss2095220497, ss2153787198, ss2627255104, ss2634850098, ss2634850099, ss2709591773, ss2711159951, ss2876542304, ss2985458499, ss2986104589, ss3004538153, ss3022917204, ss3348570207, ss3625980850, ss3636952435, ss3644988719, ss3653468368, ss3654222526, ss3672284650, ss3736393870, ss3744317644, ss3744587248, ss3769037098, ss3798740378, ss3831586943, ss3871729440, ss3919387880, ss3984617755, ss3985412212, ss5192521333, ss5237456872, ss5386658220, ss5624716126, ss5647103152, ss5828981299, ss5847353897, ss5848201854, ss5976380988, ss5979889129	NC_000009.11:22134093:T:C	NC_000009.12:22134094:T:C	(self)
59610591, 320970800, 3801010, 21857751, 714001, 69530539, 653489790, 7469868109, ss2310213898, ss3026570211, ss3723661857, ss3726601652, ss3771492532, ss3812194174, ss3965479750, ss4816112229, ss5280135098, ss5476377723, ss5572084656, ss5735693435, ss5810428235, ss5856712264, ss5915918080	NC_000009.12:22134094:T:C	NC_000009.12:22134094:T:C	(self)
ss15954995, ss18606193, ss19057714	NT_008413.16:22124093:T:C	NC_000009.12:22134094:T:C	(self)
ss230393063	NT_008413.17:22124093:T:C	NC_000009.12:22134094:T:C	(self)
ss82771277, ss104605567, ss107934366, ss120256078, ss159924101, ss181341851, ss181834428, ss181835895, ss244270289, ss410889041, ss411632917	NT_008413.18:22124093:T:C	NC_000009.12:22134094:T:C	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

223 citations for rs10811661

PMID	Title	Author	Year	Journal
17786212	Heterogeneity in meta-analyses of genome-wide association investigations.	Ioannidis JP et al.	2007	PloS one
17827400	Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.	Grarup N et al.	2007	Diabetes
17928989	Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.	Horikoshi M et al.	2007	Diabetologia
18162508	Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.	Omori S et al.	2008	Diabetes
18176561	The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.	Helgadottir A et al.	2008	Nature genetics
18224312	Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.	Brockmöller J et al.	2008	European journal of clinical pharmacology
18224336	Haplotypic analysis of Wellcome Trust Case Control Consortium data.	Browning BL et al.	2008	Human genetics
18264689	Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.	Kirchhoff K et al.	2008	Diabetologia
18368387	Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids.	Duesing K et al.	2008	Diabetologia
18423522	Estimating odds ratios in genome scans: an approximate conditional likelihood approach.	Ghosh A et al.	2008	American journal of human genetics
18426861	Association analysis of type 2 diabetes Loci in type 1 diabetes.	Qu HQ et al.	2008	Diabetes
18437351	Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).	Hertel JK et al.	2008	Diabetologia
18443202	Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.	Lewis JP et al.	2008	Diabetes
18461161	Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.	Cauchi S et al.	2008	PloS one
18469204	Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.	Ng MC et al.	2008	Diabetes
18477659	Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.	Horikawa Y et al.	2008	The Journal of clinical endocrinology and metabolism
18533027	Worldwide population differentiation at disease-associated SNPs.	Myles S et al.	2008	BMC medical genomics
18544707	Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.	Moore AF et al.	2008	Diabetes
18565990	Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.	Saccone SF et al.	2008	Bioinformatics (Oxford, England)
18591388	Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.	Lango H et al.	2008	Diabetes
18598350	Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.	Sanghera DK et al.	2008	BMC medical genetics
18633108	Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.	Wu Y et al.	2008	Diabetes
18689899	Exchangeable models of complex inherited diseases.	Slatkin M et al.	2008	Genetics
18694974	Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.	van Hoek M et al.	2008	Diabetes
18782870	Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.	Florez JC et al.	2008	The Journal of clinical endocrinology and metabolism
18991055	Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.	Lee YH et al.	2008	Journal of human genetics
19002430	Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.	Cho YM et al.	2009	Diabetologia
19008344	Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.	Rong R et al.	2009	Diabetes
19019192	Association of genetic variation on chromosome 9p21.3 and arterial stiffness.	Björck HM et al.	2009	Journal of internal medicine
19020323	Genotype score in addition to common risk factors for prediction of type 2 diabetes.	Meigs JB et al.	2008	The New England journal of medicine
19033397	Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.	Tabara Y et al.	2009	Diabetes
19033589	Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes.	Doria A et al.	2008	JAMA
19056611	Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.	Timpson NJ et al.	2009	Diabetes
19096518	Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.	Paré G et al.	2008	PLoS genetics
19207020	Meta-analysis in genome-wide association studies.	Zeggini E et al.	2009	Pharmacogenomics
19214202	Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.	Schaefer AS et al.	2009	PLoS genetics
19228808	Type 2 diabetes risk alleles are associated with reduced size at birth.	Freathy RM et al.	2009	Diabetes
19258437	Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.	van Hoek M et al.	2009	Diabetes
19279076	Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.	Qi L et al.	2009	The American journal of clinical nutrition
19324937	Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.	Brito EC et al.	2009	Diabetes
19329499	A genetic variant on chromosome 9p21 and incident heart failure in the ARIC study.	Yamagishi K et al.	2009	European heart journal
19341491	Genome-based prediction of common diseases: methodological considerations for future research.	Janssens AC et al.	2009	Genome medicine
19343170	INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.	Liu Y et al.	2009	PloS one
19401414	Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.	Takeuchi F et al.	2009	Diabetes
19455305	No association of multiple type 2 diabetes loci with type 1 diabetes.	Raj SM et al.	2009	Diabetologia
19460916	Genetic architecture of type 2 diabetes: recent progress and clinical implications.	Grant RW et al.	2009	Diabetes care
19463184	Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.	Silander K et al.	2009	Genome medicine
19474294	Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.	Hindorff LA et al.	2009	Proceedings of the National Academy of Sciences of the United States of America
19502414	Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.	Stancáková A et al.	2009	Diabetes
19526209	Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?	Southam L et al.	2009	Diabetologia
19578363	New common variants affecting susceptibility to basal cell carcinoma.	Stacey SN et al.	2009	Nature genetics
19602701	Underlying genetic models of inheritance in established type 2 diabetes associations.	Salanti G et al.	2009	American journal of epidemiology
19626703	Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies.	Yoo YJ et al.	2010	Genetic epidemiology
19734549	Ranking of genome-wide association scan signals by different measures.	Strömberg U et al.	2009	International journal of epidemiology
19741166	Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study.	Kelliny C et al.	2009	Diabetes
19741467	Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.	Kang ES et al.	2009	Transplantation
19750184	Genome-wide association studies for atherosclerotic vascular disease and its risk factors.	Ding K et al.	2009	Circulation. Cardiovascular genetics
19794065	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	Lango Allen H et al.	2010	Diabetes
19808892	Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.	't Hart LM et al.	2010	Diabetes
19819472	Common genetic variants on chromosome 9p21 predict perioperative myocardial injury after coronary artery bypass graft surgery.	Liu KY et al.	2010	The Journal of thoracic and cardiovascular surgery
19862325	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	Hu C et al.	2009	PloS one
19931040	Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.	Browning BL et al.	2009	American journal of human genetics
19956108	Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.	Cooper JD et al.	2009	Genes and immunity
19956539	How many genetic variants remain to be discovered?	Pawitan Y et al.	2009	PloS one
20017978	Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.	Fradin DD et al.	2009	BMC proceedings
20018066	Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.	An P et al.	2009	BMC proceedings
20043145	Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study.	Ruchat SM et al.	2010	Diabetologia
20043853	Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.	Parikh H et al.	2009	BMC medical genomics
20049090	Association between type 2 diabetes loci and measures of fatness.	Pecioska S et al.	2010	PloS one
20075150	Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.	Talmud PJ et al.	2010	BMJ (Clinical research ed.)
20142250	Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.	Meyer TE et al.	2010	Cancer epidemiology, biomarkers & prevention
20144327	A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.	Lott L et al.	2009	Journal of diabetes science and technology
20161033	Personalized pharmacotherapy for Type 2 diabetes mellitus.	Sathananthan A et al.	2009	Personalized medicine
20161779	Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.	Wen J et al.	2010	PloS one
20203524	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.	Pierce BL et al.	2010	Human heredity
20309761	Genotype-based risk and pharmacogenetic sampling in clinical trials.	Schork NJ et al.	2010	Journal of biopharmaceutical statistics
20362271	Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.	Ritchie MD et al.	2010	American journal of human genetics
20386740	Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.	Cunnington MS et al.	2010	PLoS genetics
20403154	Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population.	Gori F et al.	2010	BMC medical genetics
20424228	Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.	Chauhan G et al.	2010	Diabetes
20435227	Clinical assessment incorporating a personal genome.	Ashley EA et al.	2010	Lancet (London, England)
20509872	Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.	Han X et al.	2010	BMC medical genetics
20532014	The epidemiology of diabetes in Korea: from the economics to genetics.	Cho NH et al.	2010	Korean diabetes journal
20550665	Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.	Lin Y et al.	2010	BMC medical genetics
20605023	Association of an allele on chromosome 9 and abdominal aortic aneurysm.	Biros E et al.	2010	Atherosclerosis
20712903	Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.	Morgan AR et al.	2010	BMC medical genetics
20802253	Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.	Heni M et al.	2010	Diabetes
20805105	Synthetic associations in the context of genome-wide association scan signals.	Orozco G et al.	2010	Human molecular genetics
20816152	Obesity and diabetes genetic variants associated with gestational weight gain.	Stuebe AM et al.	2010	American journal of obstetrics and gynecology
20858905	Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.	Musunuru K et al.	2010	Circulation. Cardiovascular genetics
20862305	Identification of new genetic risk variants for type 2 diabetes.	Shu XO et al.	2010	PLoS genetics
20870969	Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.	Renström F et al.	2011	Diabetes
20886378	Physiologic characterization of type 2 diabetes-related loci.	Grarup N et al.	2010	Current diabetes reports
20923989	Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls.	Preuss M et al.	2010	Circulation. Cardiovascular genetics
20980412	Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study.	Uusitupa MI et al.	2011	Diabetes care
21084393	Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.	Sharma NK et al.	2011	The Journal of clinical endocrinology and metabolism
21091714	The genetics of type 2 diabetes: what have we learned from GWAS?	Billings LK et al.	2010	Annals of the New York Academy of Sciences
21103332	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.	Xu M et al.	2010	PloS one
21124985	Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.	Bell CG et al.	2010	PloS one
21146954	Genes and abdominal aortic aneurysm.	Hinterseher I et al.	2011	Annals of vascular surgery
21150882	Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia.	Karns R et al.	2011	European journal of human genetics
21191145	Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.	Mooijaart SP et al.	2011	Aging
21217814	Presymptomatic risk assessment for chronic non-communicable diseases.	Padhukasahasram B et al.	2010	PloS one
21234743	Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.	Hribal ML et al.	2011	Diabetologia
21270277	The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population.	Cheng X et al.	2011	Diabetes
21278902	Genetic risk profiling for prediction of type 2 diabetes.	Mihaescu R et al.	2011	PLoS currents
21283728	Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.	Sousa AG et al.	2011	PloS one
21297524	The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.	Devaney JM et al.	2011	Pediatric research
21315566	Type 2 diabetes and polymorphisms on chromosome 9p21: a meta-analysis.	Cugino D et al.	2012	Nutrition, metabolism, and cardiovascular diseases
21368910	Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.	Ryoo H et al.	2011	European journal of human genetics
21378175	Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.	Hivert MF et al.	2011	Diabetes
21407270	Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.	Janssens AC et al.	2011	European journal of human genetics
21421807	Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.	Stančáková A et al.	2011	Diabetes
21424820	Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration.	Janssens AC et al.	2011	European journal of epidemiology
21444075	Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.	Ewens KG et al.	2011	Fertility and sterility
21467728	Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.	Wakai K et al.	2011	Journal of epidemiology
21565292	Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies.	Han B et al.	2011	American journal of human genetics
21573907	Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.	Parra EJ et al.	2011	Diabetologia
21625859	Association between type 2 diabetes and CDKN2A/B: a meta-analysis study.	Bao XY et al.	2012	Molecular biology reports
21775993	Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction.	Shea J et al.	2011	Nature genetics
21804106	Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.	Angelakopoulou A et al.	2012	European heart journal
21911746	Effects of genetic susceptibility for type 2 diabetes on the evolution of glucose homeostasis traits before and after diabetes diagnosis: data from the D.E.S.I.R. Study.	Gautier A et al.	2011	Diabetes
22038522	Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.	Walford GA et al.	2012	Diabetologia
22052079	Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.	Gupta V et al.	2012	Diabetologia
22096510	Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.	Wang Y et al.	2011	PloS one
22113416	Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study.	Langberg KA et al.	2012	Journal of human genetics
22119613	Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population.	Nemr R et al.	2012	Diabetes research and clinical practice
22233651	A genome-wide association study of gestational diabetes mellitus in Korean women.	Kwak SH et al.	2012	Diabetes
22293688	1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.	Huang J et al.	2012	European journal of human genetics
22307069	Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial.	Peter I et al.	2012	Obesity (Silver Spring, Md.)
22333905	Estimating the contribution of genetic variants to difference in incidence of disease between population groups.	Moonesinghe R et al.	2012	European journal of human genetics
22350825	Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat.	Walker CG et al.	2012	Genes & nutrition
22364391	The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study.	Yamakawa-Kobayashi K et al.	2012	BMC medical genetics
22377712	Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.	Hotta K et al.	2012	Journal of human genetics
22558147	Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.	Winkler C et al.	2012	PloS one
22569928	Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus.	Kurzawski M et al.	2012	European journal of clinical pharmacology
22623142	Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis.	Li H et al.	2013	Acta diabetologica
22623978	A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.	Braun TR et al.	2012	PloS one
22643932	SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes.	Fagerholm E et al.	2012	Diabetologia
22676277	Vascular associated gene variants in patients with preeclampsia: results from the Danish National Birth Cohort.	Lykke JA et al.	2012	Acta obstetricia et gynecologica Scandinavica
22708638	Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial.	Godino JG et al.	2012	BMC public health
22856518	Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21.	Gioli-Pereira L et al.	2012	BMC cardiovascular disorders
22923468	Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.	Gamboa-Meléndez MA et al.	2012	Diabetes
22972441	Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications.	Murea M et al.	2012	The review of diabetic studies
23013243	Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children.	Bonilla C et al.	2012	BMC medical genetics
23073174	From genotype to human β cell phenotype and beyond.	Marchetti P et al.	2012	Islets
23134948	Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15).	Landman GW et al.	2012	Cardiovascular diabetology
23185337	Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.	Villegas R et al.	2012	PloS one
23185617	Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants.	Borglykke A et al.	2012	PloS one
23193118	Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium.	Machiela MJ et al.	2012	American journal of epidemiology
23298195	Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.	Chen G et al.	2013	Journal of diabetes
23349771	Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.	Gupta V et al.	2013	PloS one
23458876	ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.	Al-Rubeaan K et al.	2013	Gene
23532257	Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.	Ma RC et al.	2013	Diabetologia
23770741	Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.	Morris BJ et al.	2014	The journals of gerontology. Series A, Biological sciences and medical sciences
24012816	The relationship between five widely-evaluated variants in CDKN2A/B and CDKAL1 genes and the risk of type 2 diabetes: a meta-analysis.	Peng F et al.	2013	Gene
24218030	Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.	O'Brien KM et al.	2014	American journal of epidemiology
24278702	The complex interplay of genetic and lifestyle risk factors in type 2 diabetes: an overview.	Franks PW et al.	2012	Scientifica
24356749	Search for genetic determinants of sulfonylurea efficacy in type 2 diabetic patients from China.	Ren Q et al.	2014	Diabetologia
24637646	Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.	Zhao Q et al.	2014	PloS one
24719615	Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.	Basile KJ et al.	2014	International journal of endocrinology
24736664	Validation of type 2 diabetes risk variants identified by genome-wide association studies in Han Chinese population: a replication study and meta-analysis.	Chang YC et al.	2014	PloS one
24845081	Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.	Langenberg C et al.	2014	PLoS medicine
24864266	Genetics of type 2 diabetes: insights into the pathogenesis and its clinical application.	Sun X et al.	2014	BioMed research international
24926958	Evaluation of common type 2 diabetes risk variants in a South Asian population of Sri Lankan descent.	Hassanali N et al.	2014	PloS one
24929251	Gene-carbohydrate and gene-fiber interactions and type 2 diabetes in diverse populations from the National Health and Nutrition Examination Surveys (NHANES) as part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study.	Villegas R et al.	2014	BMC genetics
24935819	Exploring genetic variants predisposing to diabetes mellitus and their association with indicators of socioeconomic status.	Schmidt B et al.	2014	BMC public health
24959828	Genetic association study with metabolic syndrome and metabolic-related traits in a cross-sectional sample and a 10-year longitudinal sample of chinese elderly population.	Yang J et al.	2014	PloS one
24982668	Estimating the predictive ability of genetic risk models in simulated data based on published results from genome-wide association studies.	Kundu S et al.	2014	Frontiers in genetics
25145545	Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?	Sohani ZN et al.	2014	Diabetologia
25239271	Fine mapping of type 2 diabetes susceptibility loci.	Morris AP et al.	2014	Current diabetes reports
25393876	Identification of allelic heterogeneity at type-2 diabetes loci and impact on prediction.	Klimentidis YC et al.	2014	PloS one
25587982	Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.	Qian Y et al.	2015	PloS one
25774817	Genetics of type 2 diabetes-pitfalls and possibilities.	Prasad RB et al.	2015	Genes
25839936	Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes.	Lara-Riegos JC et al.	2015	Gene
25951190	Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology.	Drenos F et al.	2015	PloS one
26042206	Gene-gene and gene-environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India.	Uma Jyothi K et al.	2015	Meta gene
26139146	TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.	Wei F et al.	2015	Scientific reports
26240488	Utilizing Genetic Predisposition Score in Predicting Risk of Type 2 Diabetes Mellitus Incidence: A Community-based Cohort Study on Middle-aged Koreans.	Park HY et al.	2015	Journal of Korean medical science
26299860	[The HHEX rs1111875A/G gene polymorphism is associated with susceptibility to type 2 diabetes in the Iranian population].	Mansoori Y et al.	2015	Molekuliarnaia biologiia
26334876	CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population.	Binh TQ et al.	2015	BMC genetics
26499758	Association of type 2 diabetes GWAS loci and the risk of Parkinson's and Alzheimer's diseases.	Chung SJ et al.	2015	Parkinsonism & related disorders
26648684	Update on genetics and diabetic retinopathy.	Hampton BM et al.	2015	Clinical ophthalmology (Auckland, N.Z.)
26789123	A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation.	Benson KA et al.	2016	PloS one
26818947	Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.	Imamura M et al.	2016	Nature communications
26873362	Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population.	Xiao S et al.	2016	Medical science monitor
26911676	Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.	Horikoshi M et al.	2016	Human molecular genetics
26964836	Recent progress in genetic and epigenetic research on type 2 diabetes.	Kwak SH et al.	2016	Experimental & molecular medicine
27049325	Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.	Sohani ZN et al.	2016	PloS one
27053236	Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.	Gan W et al.	2016	Diabetologia
27061195	Studying the Genetics of Complex Disease With Ancestry-Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations.	Qiu J et al.	2016	Genetic epidemiology
27189021	Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.	Cook JP et al.	2016	European journal of human genetics
27281091	Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population: A case-control study.	Kong X et al.	2016	Medicine
27310578	Replication and Relevance of Multiple Susceptibility Loci Discovered from Genome Wide Association Studies for Type 2 Diabetes in an Indian Population.	Phani NM et al.	2016	PloS one
27377502	Association of CDKAL1, CDKN2A/B & HHEX gene polymorphisms with type 2 diabetes mellitus in the population of Hyderabad, India.	Kommoju UJ et al.	2016	The Indian journal of medical research
27383215	Type 2 Diabetes Risk Allele Loci in the Qatari Population.	O'Beirne SL et al.	2016	PloS one
27424552	Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.	Pranavchand R et al.	2016	Journal of postgraduate medicine
27507036	Association of rs10811656 on 9P21.3 with the risk of coronary artery disease in a Chinese population.	Yan J et al.	2016	Lipids in health and disease
27589775	Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese.	Rao P et al.	2016	International journal of environmental research and public health
27768686	Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.	Nowak C et al.	2016	PLoS genetics
28065479	Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized nutrition.	Mehramiz M et al.	2018	Clinical nutrition (Edinburgh, Scotland)
28079868	CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes.	Tarnowski M et al.	2017	Journal of perinatology
28202837	Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study.	Kasuga Y et al.	2017	Endocrine journal
28276595	A genetic variant in CDKN2A/B gene is associated with the increased risk of breast cancer.	ShahidSales S et al.	2018	Journal of clinical laboratory analysis
28717589	Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population.	Nikitin AG et al.	2017	PeerJ
28738793	Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.	Sikhayeva N et al.	2017	BMC medical genetics
28821857	CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.	Peng D et al.	2017	Scientific reports
29128291	Detection of SNPs of T2DM susceptibility genes by a ligase detection reaction-fluorescent nanosphere technique.	Chen Y et al.	2018	Analytical biochemistry
29432124	CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.	Kong Y et al.	2018	Diabetes
29498170	Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.	Zhang X et al.	2019	Addiction biology
29544538	Variants of CDKAL1 rs7754840 (G/C) and CDKN2A/2B rs10811661 (C/T) with gestational diabetes: insignificant association.	Noury AE et al.	2018	BMC research notes
29871606	Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population.	Plengvidhya N et al.	2018	BMC medical genetics
30074174	Meta-analysis of GABRB3 Gene Polymorphisms and Susceptibility to Autism Spectrum Disorder.	Noroozi R et al.	2018	Journal of molecular neuroscience
30237658	Association between gene polymorphisms and obesity and physical fitness in Korean children.	Kim HJ et al.	2018	Biology of sport
30238987	A genetic variant in CDKN2A/2B locus was associated with poor prognosis in patients with esophageal squamous cell carcinoma.	Ghobadi N et al.	2019	Journal of cellular physiology
30362613	Evaluation of the two polymorphisms rs1801133 in MTHFR and rs10811661 in CDKN2A/B in breast cancer.	Hesari A et al.	2019	Journal of cellular biochemistry
30393491	Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.	Totomoch-Serra A et al.	2018	Archives of medical science
31299695	Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes.	Dziedziejko V et al.	2019	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
32431299	Modification effects of T2DM-susceptible SNPs on the reduction of blood glucose in response to lifestyle interventions.	Wang YZ et al.	2020	Yi chuan = Hereditas
32722593	Coffee Consumption, Genetic Polymorphisms, and the Risk of Type 2 Diabetes Mellitus: A Pooled Analysis of Four Prospective Cohort Studies.	Kim AN et al.	2020	International journal of environmental research and public health
33122978	The association of a genetic variant in CDKN2A/B gene and the risk of colorectal cancer.	Rahmani F et al.	2020	EXCLI journal
35124268	Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.	Li J et al.	2022	Clinical gastroenterology and hepatology
35685576	Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.	Xu S et al.	2022	International journal of clinical practice

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs10811661