Name: rs3774426
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs3774426

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr3:53524975 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: C>G / C>T
Variation Type: SNV Single Nucleotide Variation
Frequency: T=0.288296 (76309/264690, TOPMED)
T=0.28650 (8861/30928, ALFA)
T=0.17924 (5065/28258, 14KJPN) (+ 16 more)
T=0.18073 (3029/16760, 8.3KJPN)
T=0.2378 (1523/6404, 1000G_30x)
T=0.2364 (1184/5008, 1000G)
T=0.3951 (1770/4480, Estonian)
T=0.3970 (1530/3854, ALSPAC)
T=0.4016 (1489/3708, TWINSUK)
T=0.2031 (595/2930, KOREAN)
T=0.3398 (384/1130, Daghestan)
T=0.376 (375/998, GoNL)
T=0.315 (189/600, NorthernSweden)
T=0.236 (77/326, HapMap)
C=0.391 (101/258, SGDP_PRJ)
T=0.356 (77/216, Qatari)
T=0.139 (30/216, Vietnamese)
T=0.42 (17/40, GENOME_DK)
C=0.43 (12/28, Siberian)

Clinical Significance: Not Reported in ClinVar
Gene : Consequence: CACNA1D : Intron Variant
Publications: 1 citation
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	30928	C=0.71350	G=0.00000, T=0.28650
European	Sub	19120	C=0.66721	G=0.00000, T=0.33279
African	Sub	3736	C=0.9162	G=0.0000, T=0.0838
African Others	Sub	148	C=0.959	G=0.000, T=0.041
African American	Sub	3588	C=0.9144	G=0.0000, T=0.0856
Asian	Sub	122	C=0.926	G=0.000, T=0.074
East Asian	Sub	98	C=0.93	G=0.00, T=0.07
Other Asian	Sub	24	C=0.92	G=0.00, T=0.08
Latin American 1	Sub	476	C=0.754	G=0.000, T=0.246
Latin American 2	Sub	4392	C=0.7771	G=0.0000, T=0.2229
South Asian	Sub	104	C=0.885	G=0.000, T=0.115
Other	Sub	2978	C=0.6414	G=0.0000, T=0.3586

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	C=0.711704	T=0.288296
Allele Frequency Aggregator	Total	Global	30928	C=0.71350	G=0.00000, T=0.28650
Allele Frequency Aggregator	European	Sub	19120	C=0.66721	G=0.00000, T=0.33279
Allele Frequency Aggregator	Latin American 2	Sub	4392	C=0.7771	G=0.0000, T=0.2229
Allele Frequency Aggregator	African	Sub	3736	C=0.9162	G=0.0000, T=0.0838
Allele Frequency Aggregator	Other	Sub	2978	C=0.6414	G=0.0000, T=0.3586
Allele Frequency Aggregator	Latin American 1	Sub	476	C=0.754	G=0.000, T=0.246
Allele Frequency Aggregator	Asian	Sub	122	C=0.926	G=0.000, T=0.074
Allele Frequency Aggregator	South Asian	Sub	104	C=0.885	G=0.000, T=0.115
14KJPN	JAPANESE	Study-wide	28258	C=0.82076	T=0.17924
8.3KJPN	JAPANESE	Study-wide	16760	C=0.81927	T=0.18073
1000Genomes_30x	Global	Study-wide	6404	C=0.7622	T=0.2378
1000Genomes_30x	African	Sub	1786	C=0.8578	T=0.1422
1000Genomes_30x	Europe	Sub	1266	C=0.6003	T=0.3997
1000Genomes_30x	South Asian	Sub	1202	C=0.7363	T=0.2637
1000Genomes_30x	East Asian	Sub	1170	C=0.8291	T=0.1709
1000Genomes_30x	American	Sub	980	C=0.749	T=0.251
1000Genomes	Global	Study-wide	5008	C=0.7636	T=0.2364
1000Genomes	African	Sub	1322	C=0.8608	T=0.1392
1000Genomes	East Asian	Sub	1008	C=0.8264	T=0.1736
1000Genomes	Europe	Sub	1006	C=0.6093	T=0.3907
1000Genomes	South Asian	Sub	978	C=0.731	T=0.269
1000Genomes	American	Sub	694	C=0.756	T=0.244
Genetic variation in the Estonian population	Estonian	Study-wide	4480	C=0.6049	T=0.3951
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.6030	T=0.3970
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.5984	T=0.4016
KOREAN population from KRGDB	KOREAN	Study-wide	2930	C=0.7969	T=0.2031
Genome-wide autozygosity in Daghestan	Global	Study-wide	1130	C=0.6602	T=0.3398
Genome-wide autozygosity in Daghestan	Daghestan	Sub	628	C=0.643	T=0.357
Genome-wide autozygosity in Daghestan	Near_East	Sub	142	C=0.711	T=0.289
Genome-wide autozygosity in Daghestan	Central Asia	Sub	120	C=0.675	T=0.325
Genome-wide autozygosity in Daghestan	Europe	Sub	106	C=0.575	T=0.425
Genome-wide autozygosity in Daghestan	South Asian	Sub	98	C=0.70	T=0.30
Genome-wide autozygosity in Daghestan	Caucasus	Sub	36	C=0.83	T=0.17
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	C=0.624	T=0.376
Northern Sweden	ACPOP	Study-wide	600	C=0.685	T=0.315
HapMap	Global	Study-wide	326	C=0.764	T=0.236
HapMap	African	Sub	120	C=0.867	T=0.133
HapMap	American	Sub	120	C=0.592	T=0.408
HapMap	Asian	Sub	86	C=0.86	T=0.14
SGDP_PRJ	Global	Study-wide	258	C=0.391	T=0.609
Qatari	Global	Study-wide	216	C=0.644	T=0.356
A Vietnamese Genetic Variation Database	Global	Study-wide	216	C=0.861	T=0.139
The Danish reference pan genome	Danish	Study-wide	40	C=0.57	T=0.42
Siberian	Global	Study-wide	28	C=0.43	T=0.57

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 3	NC_000003.12:g.53524975C>G
GRCh38.p14 chr 3	NC_000003.12:g.53524975C>T
GRCh37.p13 chr 3	NC_000003.11:g.53559002C>G
GRCh37.p13 chr 3	NC_000003.11:g.53559002C>T
CACNA1D RefSeqGene	NG_032999.1:g.34927C>G
CACNA1D RefSeqGene	NG_032999.1:g.34927C>T

Gene: CACNA1D, calcium voltage-gated channel subunit alpha1 D (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
CACNA1D transcript variant 1	NM_000720.4:c.483+23255C>G	N/A	Intron Variant
CACNA1D transcript variant 3	NM_001128839.3:c.483+2325… NM_001128839.3:c.483+23255C>G	N/A	Intron Variant
CACNA1D transcript variant 2	NM_001128840.3:c.483+2325… NM_001128840.3:c.483+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X14	XM_005265448.4:c.483+2325… XM_005265448.4:c.483+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X2	XM_011534094.3:c.594+2325… XM_011534094.3:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X13	XM_011534096.3:c.594+2325… XM_011534096.3:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X15	XM_011534097.3:c.57+23471… XM_011534097.3:c.57+23471C>G	N/A	Intron Variant
CACNA1D transcript variant X19	XM_011534100.3:c.594+2325… XM_011534100.3:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X1	XM_017007137.2:c.594+2325… XM_017007137.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X3	XM_017007138.2:c.594+2325… XM_017007138.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X4	XM_017007139.2:c.594+2325… XM_017007139.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X5	XM_017007140.2:c.594+2325… XM_017007140.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X6	XM_017007141.2:c.594+2325… XM_017007141.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X10	XM_017007142.2:c.594+2325… XM_017007142.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X9	XM_017007143.2:c.594+2325… XM_017007143.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X8	XM_017007144.2:c.594+2325… XM_017007144.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X11	XM_017007145.2:c.594+2325… XM_017007145.2:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X7	XM_047448871.1:c.594+2325… XM_047448871.1:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X12	XM_047448872.1:c.594+2325… XM_047448872.1:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X17	XM_047448873.1:c.594+2325… XM_047448873.1:c.594+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X18	XM_047448874.1:c.483+2325… XM_047448874.1:c.483+23255C>G	N/A	Intron Variant
CACNA1D transcript variant X16	XM_011534099.3:c.	N/A	Genic Upstream Transcript Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	C=	G	T
GRCh38.p14 chr 3	NC_000003.12:g.53524975=	NC_000003.12:g.53524975C>G	NC_000003.12:g.53524975C>T
GRCh37.p13 chr 3	NC_000003.11:g.53559002=	NC_000003.11:g.53559002C>G	NC_000003.11:g.53559002C>T
CACNA1D RefSeqGene	NG_032999.1:g.34927=	NG_032999.1:g.34927C>G	NG_032999.1:g.34927C>T
CACNA1D transcript variant 1	NM_000720.3:c.483+23255=	NM_000720.3:c.483+23255C>G	NM_000720.3:c.483+23255C>T
CACNA1D transcript variant 1	NM_000720.4:c.483+23255=	NM_000720.4:c.483+23255C>G	NM_000720.4:c.483+23255C>T
CACNA1D transcript variant 3	NM_001128839.2:c.483+23255=	NM_001128839.2:c.483+23255C>G	NM_001128839.2:c.483+23255C>T
CACNA1D transcript variant 3	NM_001128839.3:c.483+23255=	NM_001128839.3:c.483+23255C>G	NM_001128839.3:c.483+23255C>T
CACNA1D transcript variant 2	NM_001128840.2:c.483+23255=	NM_001128840.2:c.483+23255C>G	NM_001128840.2:c.483+23255C>T
CACNA1D transcript variant 2	NM_001128840.3:c.483+23255=	NM_001128840.3:c.483+23255C>G	NM_001128840.3:c.483+23255C>T
CACNA1D transcript variant X1	XM_005265448.1:c.483+23255=	XM_005265448.1:c.483+23255C>G	XM_005265448.1:c.483+23255C>T
CACNA1D transcript variant X14	XM_005265448.4:c.483+23255=	XM_005265448.4:c.483+23255C>G	XM_005265448.4:c.483+23255C>T
CACNA1D transcript variant X2	XM_011534094.3:c.594+23255=	XM_011534094.3:c.594+23255C>G	XM_011534094.3:c.594+23255C>T
CACNA1D transcript variant X13	XM_011534096.3:c.594+23255=	XM_011534096.3:c.594+23255C>G	XM_011534096.3:c.594+23255C>T
CACNA1D transcript variant X15	XM_011534097.3:c.57+23471=	XM_011534097.3:c.57+23471C>G	XM_011534097.3:c.57+23471C>T
CACNA1D transcript variant X19	XM_011534100.3:c.594+23255=	XM_011534100.3:c.594+23255C>G	XM_011534100.3:c.594+23255C>T
CACNA1D transcript variant X1	XM_017007137.2:c.594+23255=	XM_017007137.2:c.594+23255C>G	XM_017007137.2:c.594+23255C>T
CACNA1D transcript variant X3	XM_017007138.2:c.594+23255=	XM_017007138.2:c.594+23255C>G	XM_017007138.2:c.594+23255C>T
CACNA1D transcript variant X4	XM_017007139.2:c.594+23255=	XM_017007139.2:c.594+23255C>G	XM_017007139.2:c.594+23255C>T
CACNA1D transcript variant X5	XM_017007140.2:c.594+23255=	XM_017007140.2:c.594+23255C>G	XM_017007140.2:c.594+23255C>T
CACNA1D transcript variant X6	XM_017007141.2:c.594+23255=	XM_017007141.2:c.594+23255C>G	XM_017007141.2:c.594+23255C>T
CACNA1D transcript variant X10	XM_017007142.2:c.594+23255=	XM_017007142.2:c.594+23255C>G	XM_017007142.2:c.594+23255C>T
CACNA1D transcript variant X9	XM_017007143.2:c.594+23255=	XM_017007143.2:c.594+23255C>G	XM_017007143.2:c.594+23255C>T
CACNA1D transcript variant X8	XM_017007144.2:c.594+23255=	XM_017007144.2:c.594+23255C>G	XM_017007144.2:c.594+23255C>T
CACNA1D transcript variant X11	XM_017007145.2:c.594+23255=	XM_017007145.2:c.594+23255C>G	XM_017007145.2:c.594+23255C>T
CACNA1D transcript variant X7	XM_047448871.1:c.594+23255=	XM_047448871.1:c.594+23255C>G	XM_047448871.1:c.594+23255C>T
CACNA1D transcript variant X12	XM_047448872.1:c.594+23255=	XM_047448872.1:c.594+23255C>G	XM_047448872.1:c.594+23255C>T
CACNA1D transcript variant X17	XM_047448873.1:c.594+23255=	XM_047448873.1:c.594+23255C>G	XM_047448873.1:c.594+23255C>T
CACNA1D transcript variant X18	XM_047448874.1:c.483+23255=	XM_047448874.1:c.483+23255C>G	XM_047448874.1:c.483+23255C>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

68 SubSNP, 21 Frequency submissions

No	Submitter	Submission ID	Date (Build)
1	YUSUKE	ss4960489	Aug 28, 2002 (107)
2	SSAHASNP	ss21984190	Apr 05, 2004 (121)
3	ABI	ss44467742	Mar 13, 2006 (126)
4	HGSV	ss77778296	Dec 06, 2007 (129)
5	HGSV	ss80604224	Dec 14, 2007 (130)
6	HUMANGENOME_JCVI	ss96010467	Feb 04, 2009 (130)
7	ILLUMINA-UK	ss117082929	Feb 14, 2009 (130)
8	ENSEMBL	ss133215986	Dec 01, 2009 (131)
9	ILLUMINA	ss160640046	Dec 01, 2009 (131)
10	COMPLETE_GENOMICS	ss162131487	Jul 04, 2010 (132)
11	COMPLETE_GENOMICS	ss166547185	Jul 04, 2010 (132)
12	1000GENOMES	ss220135229	Jul 14, 2010 (132)
13	1000GENOMES	ss231819462	Jul 14, 2010 (132)
14	1000GENOMES	ss239233635	Jul 15, 2010 (132)
15	GMI	ss277124456	May 04, 2012 (137)
16	PJP	ss292795710	May 09, 2011 (134)
17	ILLUMINA	ss481774915	Sep 08, 2015 (146)
18	ILLUMINA	ss535860006	Sep 08, 2015 (146)
19	TISHKOFF	ss556612814	Apr 25, 2013 (138)
20	SSMP	ss650290948	Apr 25, 2013 (138)
21	EVA-GONL	ss978588877	Aug 21, 2014 (142)
22	JMKIDD_LAB	ss1070405624	Aug 21, 2014 (142)
23	1000GENOMES	ss1303999184	Aug 21, 2014 (142)
24	HAMMER_LAB	ss1397337521	Sep 08, 2015 (146)
25	DDI	ss1429418907	Apr 01, 2015 (144)
26	EVA_GENOME_DK	ss1579961400	Apr 01, 2015 (144)
27	EVA_DECODE	ss1588060218	Apr 01, 2015 (144)
28	EVA_UK10K_ALSPAC	ss1607066566	Apr 01, 2015 (144)
29	EVA_UK10K_TWINSUK	ss1650060599	Apr 01, 2015 (144)
30	WEILL_CORNELL_DGM	ss1921828556	Feb 12, 2016 (147)
31	JJLAB	ss2021473245	Sep 14, 2016 (149)
32	USC_VALOUEV	ss2149547024	Dec 20, 2016 (150)
33	HUMAN_LONGEVITY	ss2251572840	Dec 20, 2016 (150)
34	SYSTEMSBIOZJU	ss2625235115	Nov 08, 2017 (151)
35	GRF	ss2704920566	Nov 08, 2017 (151)
36	GNOMAD	ss2792966299	Nov 08, 2017 (151)
37	SWEGEN	ss2992313633	Nov 08, 2017 (151)
38	BIOINF_KMB_FNS_UNIBA	ss3024498182	Nov 08, 2017 (151)
39	CSHL	ss3345016738	Nov 08, 2017 (151)
40	ILLUMINA	ss3628660665	Oct 12, 2018 (152)
41	ILLUMINA	ss3636590615	Oct 12, 2018 (152)
42	URBANLAB	ss3647403058	Oct 12, 2018 (152)
43	EGCUT_WGS	ss3660235313	Jul 13, 2019 (153)
44	EVA_DECODE	ss3709229629	Jul 13, 2019 (153)
45	ACPOP	ss3729884312	Jul 13, 2019 (153)
46	EVA	ss3760031033	Jul 13, 2019 (153)
47	PACBIO	ss3784313684	Jul 13, 2019 (153)
48	PACBIO	ss3789829317	Jul 13, 2019 (153)
49	PACBIO	ss3794703277	Jul 13, 2019 (153)
50	KHV_HUMAN_GENOMES	ss3803166877	Jul 13, 2019 (153)
51	EVA	ss3827807740	Apr 25, 2020 (154)
52	EVA	ss3837325896	Apr 25, 2020 (154)
53	EVA	ss3842751333	Apr 25, 2020 (154)
54	SGDP_PRJ	ss3855842418	Apr 25, 2020 (154)
55	KRGDB	ss3901701076	Apr 25, 2020 (154)
56	TOPMED	ss4564697933	Apr 27, 2021 (155)
57	TOMMO_GENOMICS	ss5159163960	Apr 27, 2021 (155)
58	1000G_HIGH_COVERAGE	ss5254083747	Oct 12, 2022 (156)
59	EVA	ss5339807257	Oct 12, 2022 (156)
60	HUGCELL_USP	ss5453473897	Oct 12, 2022 (156)
61	1000G_HIGH_COVERAGE	ss5532450755	Oct 12, 2022 (156)
62	SANFORD_IMAGENETICS	ss5632126993	Oct 12, 2022 (156)
63	TOMMO_GENOMICS	ss5690831377	Oct 12, 2022 (156)
64	YY_MCH	ss5803736599	Oct 12, 2022 (156)
65	EVA	ss5825753371	Oct 12, 2022 (156)
66	EVA	ss5853610245	Oct 12, 2022 (156)
67	EVA	ss5868830843	Oct 12, 2022 (156)
68	EVA	ss5960420438	Oct 12, 2022 (156)
69	1000Genomes	NC_000003.11 - 53559002	Oct 12, 2018 (152)
70	1000Genomes_30x	NC_000003.12 - 53524975	Oct 12, 2022 (156)
71	The Avon Longitudinal Study of Parents and Children	NC_000003.11 - 53559002	Oct 12, 2018 (152)
72	Genome-wide autozygosity in Daghestan	NC_000003.10 - 53534042	Apr 25, 2020 (154)
73	Genetic variation in the Estonian population	NC_000003.11 - 53559002	Oct 12, 2018 (152)
74	The Danish reference pan genome	NC_000003.11 - 53559002	Apr 25, 2020 (154)
75	gnomAD - Genomes Submission ignored due to conflicting rows: Row 107827462 (NC_000003.12:53524974:C:G 14/140070) Row 107827463 (NC_000003.12:53524974:C:T 42822/140038)	-	Apr 27, 2021 (155)
76	gnomAD - Genomes Submission ignored due to conflicting rows: Row 107827462 (NC_000003.12:53524974:C:G 14/140070) Row 107827463 (NC_000003.12:53524974:C:T 42822/140038)	-	Apr 27, 2021 (155)
77	Genome of the Netherlands Release 5	NC_000003.11 - 53559002	Apr 25, 2020 (154)
78	HapMap	NC_000003.12 - 53524975	Apr 25, 2020 (154)
79	KOREAN population from KRGDB	NC_000003.11 - 53559002	Apr 25, 2020 (154)
80	Northern Sweden	NC_000003.11 - 53559002	Jul 13, 2019 (153)
81	Qatari	NC_000003.11 - 53559002	Apr 25, 2020 (154)
82	SGDP_PRJ	NC_000003.11 - 53559002	Apr 25, 2020 (154)
83	Siberian	NC_000003.11 - 53559002	Apr 25, 2020 (154)
84	8.3KJPN	NC_000003.11 - 53559002	Apr 27, 2021 (155)
85	14KJPN	NC_000003.12 - 53524975	Oct 12, 2022 (156)
86	TopMed	NC_000003.12 - 53524975	Apr 27, 2021 (155)
87	UK 10K study - Twins	NC_000003.11 - 53559002	Oct 12, 2018 (152)
88	A Vietnamese Genetic Variation Database	NC_000003.11 - 53559002	Jul 13, 2019 (153)
89	ALFA	NC_000003.12 - 53524975	Apr 27, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs57215342	May 23, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss2792966299	NC_000003.11:53559001:C:G	NC_000003.12:53524974:C:G	(self)
5252711844, ss2251572840	NC_000003.12:53524974:C:G	NC_000003.12:53524974:C:G	(self)
ss77778296, ss80604224	NC_000003.9:53534041:C:T	NC_000003.12:53524974:C:T	(self)
313523, ss117082929, ss162131487, ss166547185, ss277124456, ss292795710, ss1397337521, ss1588060218	NC_000003.10:53534041:C:T	NC_000003.12:53524974:C:T	(self)
15187050, 8446459, 5973561, 6126339, 3703439, 8878470, 3169177, 3870486, 7859398, 2063378, 17133267, 8446459, 1834090, ss220135229, ss231819462, ss239233635, ss481774915, ss535860006, ss556612814, ss650290948, ss978588877, ss1070405624, ss1303999184, ss1429418907, ss1579961400, ss1607066566, ss1650060599, ss1921828556, ss2021473245, ss2149547024, ss2625235115, ss2704920566, ss2792966299, ss2992313633, ss3345016738, ss3628660665, ss3636590615, ss3660235313, ss3729884312, ss3760031033, ss3784313684, ss3789829317, ss3794703277, ss3827807740, ss3837325896, ss3855842418, ss3901701076, ss5159163960, ss5339807257, ss5632126993, ss5825753371, ss5960420438	NC_000003.11:53559001:C:T	NC_000003.12:53524974:C:T	(self)
19976690, 2358736, 24668481, 402075488, 5252711844, ss2251572840, ss3024498182, ss3647403058, ss3709229629, ss3803166877, ss3842751333, ss4564697933, ss5254083747, ss5453473897, ss5532450755, ss5690831377, ss5803736599, ss5853610245, ss5868830843	NC_000003.12:53524974:C:T	NC_000003.12:53524974:C:T	(self)
ss21984190	NT_022517.16:53481349:C:T	NC_000003.12:53524974:C:T	(self)
ss4960489, ss44467742, ss96010467, ss133215986, ss160640046	NT_022517.18:53499001:C:T	NC_000003.12:53524974:C:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

1 citation for rs3774426

PMID	Title	Author	Year	Journal
19225208	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	Kamide K et al.	2009	Circulation journal

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
Top▲ Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs3774426